H6916

Macrophage Colony-Stimulating Factor human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

• Sinónimos: MCSF
• Número MDL: MFCD00166591
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Macrophage Colony-Stimulating Factor human, M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture
• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in HEK 293 cells
• Ensayo: ≥95% (SDS-PAGE)
• Formulario: lyophilized powder
• potencia: ≤4 ng/mL EC₅₀
• calidad: endotoxin tested
• mol peso: dimer 35-40 kDa (glycosylated)
• envase: pkg of 10 μg
• fabricante / nombre comercial: HumanZyme
• técnicas: cell culture | mammalian: suitable
• Nº de acceso UniProt: P09603
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CSF1(1435)

Descripción

Descripción general

M-CSF is encoded by the gene mapped to human chromosome 1p13.3.[1] It is a glycosylated polypeptide, which exists as a homodimer.[2] M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.[3]

Acciones bioquímicas o fisiológicas

Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells.[3][4] It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages.[5] In addition, human M-CSF inhibits bone resorption by osteoclasts.[6] It might also play a crucial role in atherosclerosis.[3] Overexpression of the gene has been observed in Paget′s disease of bone (PDB).[1]

Forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de análisis

The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable