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MilliporeSigma

GW22299F

Sigma-Aldrich

Anti-M6PRBP1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

chicken

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

reactividad de especies

human

fabricante / nombre comercial

Genway 15-288-22299F

técnicas

western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... M6PRBP1(10226)

Descripción general

M6PRBP1 (Mannose-6-phosphate receptor binding protein 1) is a lipid droplet-associated protein, which is highly expressed, especially in adipocytes. It is also called perilipin 3 (PLIN3), and is a member of the PAT (perilipin, adipophilin, and the tail-interacting protein 47kDa) family of proteins, which includes five members. The N-terminal of this protein contains PAT-1 domain, and the C-terminal contains the PAT-2 domain. Both these domains are highly conserved regions.

Inmunógeno

Immunogen Sequence: GI # 20127486, sequence 1-434
Recombinant mannose 6 phosphate receptor binding protein 1

Aplicación

Anti-M6PRBP1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Acciones bioquímicas o fisiológicas

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) has apolipoprotein-like properties and reorganizes liposomes into small lipid discs and plays a function in the biogenesis of cytosolic lipid droplets (LD). M6PRBP1 has a pivotal role in cytosolic lipid droplets (LD)-biogenesis in HL-60-derived neutrophils. It is associated with the synthesis and secretion of PGE2. M6PRBP1 also acts positively on HIV-1 and vaccinia virus production.

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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Anna V Bulankina et al.
The Journal of cell biology, 185(4), 641-655 (2009-05-20)
TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo selection device for mannose 6-phosphate receptors (MPRs), directing their transport from endosomes to the trans-Golgi network. In contrast, our current analysis shows that cytosolic TIP47 is not recruited to
Carole Bampi et al.
Virus research, 173(2), 354-363 (2013-01-26)
The cellular tail-interacting 47-kDa protein (TIP47) acts positively on HIV-1 and vaccinia virus production. We show here that TIP47, in contrast, acts as a restriction factor for Sendai virus production. This conclusion is supported by the occurrence of increased or
Jeffrey D Covington et al.
PloS one, 9(3), e91675-e91675 (2014-03-19)
Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis. We aimed here to explore the
Fuyuki Nose et al.
PloS one, 8(8), e71542-e71542 (2013-08-13)
Cytosolic lipid droplets (LDs), which are now recognized as multifunctional organelles, accumulate in leukocytes under various inflammatory conditions. However, little is known about the characteristic features of LDs in neutrophils. In this study, we show that perilipin-3 (PLIN3; formerly called
Jeffrey D Covington et al.
European journal of endocrinology, 172(1), 47-58 (2014-10-25)
Polycystic ovary syndrome (PCOS) is associated with reduced adipose tissue lipolysis that can be rescued by aerobic exercise. We aimed to identify differences in the gene expression of perilipins and associated targets in adipose tissue in women with PCOS before

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