GW21980B

Anti-CARD14 (ab2) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-CARD-containing MAGUK protein 2, Anti-Caspase recruitment domain-containing protein 14
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: chicken
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• fabricante / nombre comercial: Genway 15-288-21980B
• técnicas: western blot: suitable
• Nº de acceso NCBI: NP_438170.1
• Nº de acceso UniProt: Q9BXL6
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... CARD14(79092)

Descripción

Descripción general

The gene CARD14 (caspase recruitment domain family member 14) encodes a member of the MAGUK (membrane-associated guanylate kinase) family of proteins. These proteins are scaffold proteins that participate in the assembly of multiprotein complexes at certain sites on the plasma membrane. The encoded protein contains an N-terminal CARD domain, a central coiled-coil domain, and a tripartite domain comprising of a PDZ (PSD-95, Dlg1, ZO-1) domain, an Src (Sarcoma) homology 3 domain, and a GUK (Guanylate kinase) domain at the C-terminus. The gene is mapped to human chromosome 17q25. It is mainly expressed in the basal and suprabasal layers of healthy skin epidermis.

Inmunógeno

Immunogen Sequence: GI # 16507955, sequence 221-330

Recombinant caspase recruitment domain protein 14 isoform 2

Acciones bioquímicas o fisiológicas

The gene CARD14 (caspase recruitment domain family member 14) encodes a nuclear factor that contains a CARD domain involved in binding to the CARD domain of BCL10 (B cell leukemia 10), a protein involved in the activation of NF-κB through the IKK complex, and positive regulation of apoptosis. Mutations in this gene are associated with familial pityriasis rubra pilaris, a papulosquamous disorder phenotypically related to psoriasis. It also activates p38 and JNK MAP (c-Jun N-terminal kinase mitogen-activated protein) kinase pathways via association with paracaspase-1 (PCASP-1), also referred to as MALT1, which can serve as a therapeutic target in psoriasis.[1]

Forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)