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MilliporeSigma

GW21213

Sigma-Aldrich

Anti-KCMF1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Hypothetical protein KCMF1, Anti-PCMF, Anti-Potassium channel modulatory factor

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21213

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KCMF1(56888)

Immunogen

Immunogen Sequence: GI # 10047128, sequence 280-375
Recombinant potassium channel modulatory factor

Application

Anti-KCMF1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

KCMF1 (DEBT91) is mapped to chromosome 2p11.2 in humans. It encodes a 381 amino acid molecule with high Ser and Thr composition and is highly conserved at its N-terminus across species. DEBT91 is suggested to be a coiled-coil nuclear phosphoprotein with zinc finger motifs at the N-terminal conserved region, which is rich in cysteine and histidine. It is an immediate early gene up-regulated during growth factor-induced branching tubulogenesis. DEBT91 plays an important role in gastric carcinogenesis. Its upregulation in response to bFGF in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificados de análisis (COA)

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Jun-Hyeog Jang
FEBS letters, 578(1-2), 21-25 (2004-12-08)
We have previously shown that fibroblast growth factor receptor 2 (FGFR2) plays an important role in gastric carcinogenesis. In this study, we have used a differential display approach to identify basic fibroblast growth factor (bFGF)-inducible genes in gastric cancer cells.
Zhixing Li et al.
Biochemical and biophysical research communications, 306(3), 623-628 (2003-06-18)
In a differential screen for genes that might be important in the regulation of epithelial morphogenesis, we identified a novel gene, Debt91 (differentially expressed in branching tubulogenesis), which is up-regulated in an in vitro model of renal tubulogenesis and branching.

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