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GW21069

Sigma-Aldrich

Anti-CCL7 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-MARC, Anti-MCP3, Anti-Monocyte chemotactic protein 3, Anti-SCYA7, Anti-Small inducible cytokine A7

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About This Item

MDL number:
MFCD01092423
UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

manufacturer/tradename

Genway 15-288-21069

technique(s)

western blot: suitable

NCBI accession no.

NP_006264.2

UniProt accession no.

P80098

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCL7(6354)

Immunogen

Immunogen Sequence: GI # 13435402, sequence 25-66
Recombinant chemokine (C-C motif) ligand 7

Application

Anti-CCL7 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine, earlier called as monocyte-specific chemokine 3 (MCP3). It regulates macrophage functions. It belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines and is produced by astrocytes. The CCL7 gene is mapped to chromosome 17 on subbands q11.2-q12. It induces production of gelatinase B and chemotaxis of monocytes. It is often produced by tumor cell lines and regulates protease secretion by macrophages. CCL7 production may contribute to invasion and metastasis of cancer cells. It may act as a novel target metastasis of colorectal cancer (CRC) and may be of potential clinical value for the prevention of hepatic recurrences. CCL7 may have a role in vascular pathology as well.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Marcella Maddaluno et al.
Atherosclerosis, 217(1), 113-119 (2011-05-04)
Monocyte chemotactic protein-3 (MCP-3), also known as CCL7, belongs to the monocyte chemotactic protein (MCP) subfamily of the CC chemokines that includes MCP-1/CCL2, MCP-2/CCL8, MCP-4/CCL13, and MCP-5/CCL12. Few studies have examined the role of MCP-3 in vascular pathologies such as
G Opdenakker et al.
Biochemical and biophysical research communications, 191(2), 535-542 (1993-03-15)
When human MG-63 osteosarcoma cells are triggered with IL-1 beta, they produce, among various other cytokines, also monocyte chemotactic proteins (MCPs). Homogeneous MCP-1, MCP-2 and MCP-3 were found to induce production of gelatinase B and chemotaxis of monocytes. Based on
G Opdenakker et al.
Genomics, 21(2), 403-408 (1994-05-15)
Monocyte chemotactic proteins (MCPs) are chemokines involved in macrophage recruitment during inflammation and cancer. A full-size MCP-3 cDNA was used to isolate the functional human MCP-3 gene. Based on restriction analysis, subclones were selected and the MCP-3 gene sequence was
Yong Beom Cho et al.
Oncology reports, 28(2), 689-694 (2012-05-23)
The main cause of death for colorectal cancer (CRC) patients is the development of metastatic lesions at sites distant from the primary tumor. Therefore, it is important to find biomarkers that are related to the metastasis and to study the
Nicole A Renner et al.
Journal of neurovirology, 17(2), 146-152 (2011-02-01)
Monocyte/macrophages and activated lymphocytes traffic through normal brain, and this trafficking is increased in inflammatory conditions such as HIV encephalitis (HIVE). HIVE is characterized in part by perivascular accumulations of macrophages. The earliest events in this process are poorly understood

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