All FSL constructs disperse in biocompatible media and spontaneously and stably incorporate into cell membranes. Cells modified with KODE constructs are known as kodecytes and usually maintain their normal vitality and functionality.
FSL-B(tri) has been specifically designed to create live cells (kodecytes) expressing blood group B antigens but can also be used to modify other hydrophobic surfaces including fixed cells, virions, and solid phase surfaces. This product can be used to attach reproducible and controlled levels of blood group B antigens (generic B due to its trisaccharide structure) to group O or A erythrocytes. These kodecytes will react with most anti-B blood grouping reagents including polyclonal reagents.
All FSL constructs disperse in biocompatible media and spontaneously and stably incorporate into cell membranes. FSL-B(tri) has been specifically designed to create live cells (kodecytes) expressing blood group B antigens but can also be used to modify other hydrophobic surfaces including fixed cells, virions, and solid phase surfaces.
FSL-B(tri) has been used to modify cell or virion surfaces with markers.[1]
Otras notas
FSL-B(tri) is a KODE™ technology construct designed to label hydrophobic surfaces including living cells with blood group B trisaccharide. All KODE FSL constructs consist of three essential designable features: a functional component (F), a spacer (S), and a diacyl lipid (L). FSL-B(tri) is comprised of the blood group B trisaccharide Galα3(Fucα2)Galβ representing F, conjugated via an O(CH2)3NH spacer (SA1) to an activated adipate derivative of dioleoylphosphatidylethanolamine (L1).
Información legal
KODE Constructs are supplied by KODE Biotech Materials Limited under license from KODE Biotech Limited.
FSL Constructs: A Simple Method for Modifying Cell/Virion Surfaces with a Range of Biological Markers Without Affecting their Viability
D.A. Blake
Journal of Visualized Experiments (2011)
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