F8681

Anti-FURIN (106-120) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinónimos: Anti-FUR, Anti-FURIN Furin precursor, Anti-PACE, Anti-PCSK3, Anti-SPC1
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~87 kDa
• species reactivity: human
• technique(s): western blot: 1:250-1:500
• UniProt accession no.: P09958
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FURIN(5045)

Descripción

General description

Furin is an endoprotease and belongs to the eukaryotic subtilisin family. It is synthesized as membrane-anchored endoproteases. Furin is colocalized mainly in the trans-golgi network although it is available in between this compartment and the cell surface to some lesser extent. It is the first identified proprotein convertase.

Immunogen

synthetic peptide corresponding to amino acids 106-120 of human FURIN

Application

Anti-FURIN (106-120) antibody is suitable for western blot analysis at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

Furin plays a vital role in cleaving of a wide variety of proteins, including growth factors, serum proteins, including proteases of the blood-clotting and complement systems, matrix metalloproteinases, receptors, viral-envelope glycoproteins and bacterial exotoxins.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)