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F2802

Fluvoxamine maleate

Name: Fluvoxamine maleate
Brand: SIGMA
Price: 105 USD
Availability: InStock

neuronal serotonin reuptake inhibitor, solid

Sinónimos:

(E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-O-(2-aminoethyl)oxime maleate

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Tamaño de envase	SKU	Disponibilidad	Precio
10 mg		Disponible para enviar HOYdesdeMILWAUKEE	$105.00
50 mg		Disponible para enviar HOYdesdeMILWAUKEE	$464.00

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₅H₂₁F₃N₂O₂ · C₄H₄O₄

Número CAS:

61718-82-9

Peso molecular:

434.41

UNSPSC Code:

12352116

PubChem Substance ID:

24278162

NACRES:

NA.77

MDL number:

MFCD00269809

Form:

solid

Quality level:

200

$105.00

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Nombre del producto

Fluvoxamine maleate, solid

form

solid

Quality Level

200

solubility

H₂O: soluble

originator

Solvay

storage temp.

2-8°C

SMILES string

COCCCC/C(C1=CC=C(C(F)(F)F)C=C1)=N\OCCN.OC(/C=C\C(O)=O)=O

InChI

1S/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-

InChI key

LFMYNZPAVPMEGP-PIDGMYBPSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

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Este artículo	PHR1793	F-040	BP600
Sigma-Aldrich F2802 Fluvoxamine maleate	Supelco PHR1793 Fluvoxamine Maleate	Supelco F-040 Fluvoxamine maleate	BP600 Fluvoxamine maleate
form solid	form solid	form liquid	form solid
Quality Level 200	Quality Level 300	Quality Level 300	Quality Level -
storage temp. 2-8°C	storage temp. 2-30°C	storage temp. −20°C	storage temp. 2-8°C
solubility H₂O: soluble	solubility -	solubility -	solubility -
originator Solvay	originator -	originator -	originator -
Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)	Gene Information human ... SLC6A4(6532)	Gene Information human ... SLC6A4(6532)	Gene Information human ... SLC6A4(6532)

Application

Fluvoxamine maleate has been used as a test compound to determine the solubility and effective blood-brain barrier permeability.(2)

Biochem/physiol Actions

Fluvoxamine maleate is a selective neuronal serotonin reuptake inhibitor. It functions as an antidepressant and anti-obsessive agent. It is useful in treating obsessive compulsive disorder and panic disorder.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Solvay. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number

0000472208

0000468273

0000468272

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Mosby's Drug Reference for Health Professions null

A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction.

Eiko Sunami et al.

Internal medicine (Tokyo, Japan), 51(10), 1187-1193 (2012-06-13)

Antidepressants have been recommended for the treatment of post-stroke depression (PSD). The purpose of this study was to evaluate the effect of fluvoxamine maleate, a selective serotonin re-uptake inhibitor (SSRI), on depressive state, sleep disturbance, and serum melatonin levels in

Involvement of the sigma1 receptor in the antidepressant-like effects of fluvoxamine in the forced swimming test in comparison with the effects elicited by paroxetine.

Yumi Sugimoto et al.

European journal of pharmacology, 696(1-3), 96-100 (2012-10-09)

We studied the involvement of the sigma(1) receptor in the antidepressant-like effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in DBA/2 mice using the forced swimming test. The effects of the selective sigma(1) receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) at

Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.

Michihiko Iijima et al.

Behavioural brain research, 235(2), 287-292 (2012-08-28)

Accumulated evidence indicates that metabotropic glutamate 5 (mGlu5) receptor blockade exerts antidepressant-like and anxiolytic-like effects in several animal models. The novelty-suppressed feeding (NSF) test is used to measure anxiety-induced hypophagia in rodents. Anxiogenic-like behavior can be counteracted by acute treatment

In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine.

Natalia Mast et al.

Molecular pharmacology, 82(5), 824-834 (2012-08-04)

Cytochrome P450 46A1 (cholesterol 24-hydroxylase) is an important brain enzyme that may be inhibited by structurally distinct pharmaceutical agents both in vitro and in vivo. To identify additional inhibitors of CYP46A1 among U.S. Food and Drug Administration-approved therapeutic agents, we

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Número de artículo de comercio global

SKU	GTIN
F2802-10MG	04061833613320
F2802-50MG	04061832082073

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