F0267
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys
≥97% (HPLC)
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About This Item
Fórmula empírica (notación de Hill):
C43H65N7O9
Número de CAS:
Peso molecular:
824.02
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
Ensayo
≥97% (HPLC)
temp. de almacenamiento
−20°C
cadena SMILES
CCCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCC)C(=O)NC(Cc2ccc(O)cc2)C(=O)NC(CCCCN)C(O)=O
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Acciones bioquímicas o fisiológicas
Potent chemoattractant for human neutrophils.
Radioiodinated molecule has full biological activity.
Radioiodinated molecule has full biological activity.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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G Vaidyanathan et al.
Nuclear medicine and biology, 22(6), 759-764 (1995-08-01)
A potent chemotactic peptide, formyl-norleucyl-leucyl-phenylalanyl-norleucyl-tyrosyl-lysine was derivatized by reaction with N-succinimidyl 4-fluorobenzoate. This derivatized peptide bound to human polymorphonuclear leukocytes in vitro and exhibited biological activity in a superoxide production assay. Peptide labeling using N-succinimidyl 4-[18F]fluorobenzoate was accomplished in reasonable
A Volz
Journal of cell science, 106 ( Pt 2), 493-501 (1993-10-01)
The study analyses the distribution and quantitative expression of surface CD18 of neutrophils exposed to distinct stimuli that produce different types of continuous shape changes, including types that are associated with locomotion and others that are not. The chemotactic peptide
L A Sklar et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(12), 7540-7544 (1981-12-01)
Antifluorescein antibody molecules were used to interrupt the stimulation of neutrophils by a fluoresceinated chemotactic peptide. From the results we construct a semiquantitative relationship among ligand-receptor interaction, the time course of cell triggering and response, and aspects of cellular adaptation.
V Radhika et al.
American journal of hematology, 52(3), 155-164 (1996-07-01)
Binding of chemoattractant to polymorphonuclear leukocytes (PMNL) triggers a series of events like polymerization of actin and tubulin, orientation of cells, chemotaxis, increase in fluid pinocytosis and phagocytosis, and stimulation of microbicidal pathways which includes lysosomal degranulation and generation of
V Niggli et al.
European journal of pharmacology, 335(1), 43-52 (1997-11-26)
To define a possible role of the enzyme phosphatidylinositol 3-kinase (PI 3-kinase) in motile functions of neutrophils, we have used a potent inhibitor of this enzyme, [1S-(1alpha,6b alpha,9a beta,11alpha,11bbeta)]-1-(acetyloxy)-1,6b,7,8,9a,10,11 ,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno [4,5-h]-2-benzopyran-3,6,9-trione (wortmannin). Wortmannin markedly attenuated chemotactic peptide-induced development of polarity
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