E8027
EphA2/Fc Chimera from mouse
>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Sinónimos:
Eck, Myk2, Sek
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About This Item
Número MDL:
Código UNSPSC:
51111800
origen biológico
mouse
recombinante
expressed in NSO cells
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
potencia
0.078-5 ng/mL
mol peso
monomer calculated mol wt 84 kDa
~105 kDa by SDS-PAGE (reducing)
envase
pkg of 200 μg
condiciones de almacenamiento
avoid repeated freeze/thaw cycles
técnicas
ligand binding assay: suitable
impurezas
endotoxin, tested
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
mouse ... Epha2(13836)
Descripción general
EPHA2 (ephrin receptor A2) belongs to the Eph family of receptor tyrosine kinases. It is a type I transmembrane protein, and its exoplasmic domain consists of a ligand binding domain in its N-terminal, a cysteine-rich domain, and two fibronectin type III repeats. Its cytoplasmic domain contains a juxtamembrane region, a tyrosine kinase domain, a SAM (sterile-a-motif) motif, and a PDZ-binding domain.
Acciones bioquímicas o fisiológicas
EPHA2 binds to the ephrin-A ligand and has diverse cellular function. EPHA2 has been shown to be an oncoprotein of importance in a range of cancers. EPHA2 is overexpressed in several human cancer types and promotes malignancy through a mechanism involving RhoA-dependent destabilization of adherens junctions. EPHA2 overexpression induces a FAK-dependent increase in MMP-2 expression and invasiveness and this process that can be reversed by ligation of EPHA2.
Member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1, ephrin-A2, ephrin-A3, ephrin-A4, and ephrin-A5; involved in pattern formation and morphogenesis. EphA2 is expressed on endothelial cells and in tumor xenographs and may regulate tumor neovascularization.
Otras notas
Extracellular domain of mouse EphA2 (amino acids 1-535) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.
Forma física
Lyophilized from a 0.2 μm filtered solution in 20 mM Tris, pH 8.0.
Nota de análisis
The biological activity is measured by its ability to bind recombinant mouse ephrin-A1/Fc in an ELISA assay.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Mark S Duxbury et al.
Biochemical and biophysical research communications, 320(4), 1096-1102 (2004-07-14)
The Eph tyrosine kinases interact with ligands of the Ephrin family and have diverse cellular functions. EphA2 has been recognized to be an oncoprotein of importance in a range of cancers. Here, we examine the effect of EphA2 overexpression and
Wei Bin Fang et al.
Journal of cell science, 121(Pt 3), 358-368 (2008-01-17)
EPHA2 receptor tyrosine kinase is overexpressed in several human cancer types and promotes malignancy. However, the mechanisms by which EPHA2 promotes tumor progression are not completely understood. Here we report that overexpression of a wild-type EPHA2, but not a signaling-defective
Linda M Reis et al.
Molecular vision, 20, 836-842 (2014-06-19)
Congenital cataracts occur in 3-4 per 10,000 live births and account for 5% to 20% of pediatric blindness worldwide. With more than 37 genes known to be associated with isolated congenital cataract, whole exome sequencing (WES) was recently introduced as
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