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E4642
(±)-Epinephrine hydrochloride
≥98% (TLC), powder, adrenergic receptor agonist
Sinónimos:
(±)-Adrenalin, 4-(1-Hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride
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5 G
$81.51
25 G
$355.00
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5 G
$81.51
25 G
$355.00
About This Item
Fórmula empírica (notación de Hill):
C9H13NO3 · HCl
Número de CAS:
Peso molecular:
219.67
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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Nombre del producto
(±)-Epinephrine hydrochloride,
Quality Level
solubility
H2O: 50 mg/mL
storage temp.
2-8°C
SMILES string
OC(CNC)C1=CC=C(O)C(O)=C1.Cl
InChI
1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
InChI key
ATADHKWKHYVBTJ-UHFFFAOYSA-N
Gene Information
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)
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General description
Epinephrine (adrenalin) is synthesized from norepinephrine (noradrenalin) by the action of the enzyme phenylethanolamine N-methyltransferase. Epinephrine comprises 5%-10% of the total catecholamines in the central nervous system.[1] It is a mixed α/β-adrenergic receptor agonist and stimulates these receptors.[2] Their site of synthesis is adrenal medulla and it travels through the vascular systems. Its breakdown occurs in the central nervous system (CNS), liver and kidney.[3]
Application
(±)-Epinephrine hydrochloride has been used:
- in the induction of renalase expression in Human renal proximal tubular epithelial cells[4]
- in the infusion studies to test its effect on heart rate and eye temperature measurements in bull[5]
- as a medium supplement for the stimulation of endothelial progenitor cells[6]
Biochem/physiol Actions
Epinephrine improves systemic pressure during cardiopulmonary resuscitation and is used post cardiac arrest. The levels of epinephrine increases during trauma, sepsis and hypoglycemia resulting in increased cardiac rate and contractility.[3] It is used in the treatment of acute anaphylaxis.[7] Use of epinephrine hydrochloride enables dilation of pupil during intraocular lens (IOL) implantation surgery.[8]
Adrenergic receptor agonist.
Other Notes
The ratio of +/- adrenaline is not determined.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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est ce que l'epinephrine de degrade a 37C et est ce qu'il est reversible?
1 answer-
Helpful?
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Can it be stored at -20C
1 answer-
The recommended storage temperature for this product is 2-8°C. In general, powder materials are not affected by freezer storage, however, this item has not been tested under these storage conditions.
Helpful?
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Hi, Do you have the ratio/ amount of D- and L-adrenaline in this product?
1 answer-
The ratio of +/- adrenaline is not determined.
Helpful?
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