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E1024

β-Estradiol

meets USP testing specifications

Sinónimos:

β-Estradiol, 1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin

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E1024-1G

$55.80

E1024-25G

$790.00

E1024-100G

$2,710.00

$55.80

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Fórmula empírica (notación de Hill):
C18H24O2
Número CAS:
50-28-2
Peso molecular:
272.38
UNSPSC Code:
12352104
NACRES:
NA.21
PubChem Substance ID:
24894380
EC Number:
200-023-8
Beilstein/REAXYS Number:
1914275
MDL number:
MFCD00003693

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InChI key

VOXZDWNPVJITMN-ZBRFXRBCSA-N

InChI

1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

SMILES string

O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

agency

USP/NF, meets USP testing specifications

form

powder

Quality Level

200

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

mp

176-180 °C (lit.)

application(s)

pharmaceutical (small molecule)

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Este artículo
PHR1353E2257E1132
Estradiol meets USP testing specifications

Sigma-Aldrich

E1024

Estradiol

Estradiol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1353

Estradiol

β-Estradiol powder, γ-irradiated, suitable for cell culture

Sigma-Aldrich

E2257

β-Estradiol

β-Estradiol analytical standard

Sigma-Aldrich

E1132

β-Estradiol

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

200

form

powder

form

-

form

powder

form

-

mp

176-180 °C (lit.)

mp

176-180 °C (lit.)

mp

176-180 °C (lit.)

mp

176-180 °C (lit.)

agency

USP/NF

agency

traceable to BP 729, traceable to Ph. Eur. E1620000, traceable to USP 1250008

agency

-

agency

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Gene Information

human ... ESR1(2099)

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Gene Information

human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
The major estrogen secreted by the premenopausal ovary.

pictograms

Health hazardEnvironment
GHS08,GHS09

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000537002
0000537002
0000514485
0000514485
0000468502

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Fiona C Baker et al.
Psychoneuroendocrinology, 60, 96-104 (2015-07-05)
The menopausal transition is marked by increased prevalence in disturbed sleep and insomnia, present in 40-60% of women, but evidence for a physiological basis for their sleep complaints is lacking. We aimed to quantify sleep disturbance and the underlying contribution
Martial Pré et al.
Plant physiology, 147(3), 1347-1357 (2008-05-10)
Plant defense against pathogens depends on the action of several endogenously produced hormones, including jasmonic acid (JA) and ethylene. In certain defense responses, JA and ethylene signaling pathways synergize to activate a specific set of defense genes. Here, we describe
Agnete Overgaard et al.
Endocrinology, 155(10), 3945-3955 (2014-07-23)
Kisspeptin, neurokinin B (NKB) and dynorphin A are coexpressed in a population of neurons in the arcuate nucleus (ARC), termed KNDy neurons, which were recently recognized as important elements for the generation of GnRH pulses. However, the topographic distribution of
Erika Comasco et al.
Human brain mapping, 35(9), 4450-4458 (2014-03-13)
Premenstrual dysphoric disorder (PMDD) is the prototypical sex-specific disorder in which symptom onset and offset require a particular hormonal milieu and for which there is moderate heritability. The present study investigated brain emotion processing in PMDD and healthy controls, as
Hirotaka Ishii et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 13(4), 323-334 (2007-07-24)
It is believed that sex hormones are synthesized in the gonads and reach the brain via the blood circulation. In contrast with this view, the authors have demonstrated that sex hormones are also synthesized locally in the hippocampus and that
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Questions

1–8 of 8 Questions  

  1. Is your estradiol and testosterone sterile?

    1 answer

    1. This product is not sterile. Prepared solutions would need to be filter-sterilized. Please see the link below to review a sterile Estradiol product option:
      https://www.sigmaaldrich.com/product/sigma/e2257

      Currently, a sterile testosterone product is not available. Testosterone product T1500, while not sterile or tested for use in cell culture, has been used successfully by other researchers in culture applications. Please see the link below to review an example publication:
      https://www.sciencedirect.com/science/article/pii/S0090955624033695?via%3Dihub

      Please see the link below to review this testosterone product option:
      https://www.sigmaaldrich.com/product/sigma/t1500

      Helpful?

  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. Is product E1024 soluble in DMSO? If so, what is the recommended initial stock concentration to make?

    1 answer

    1. This product has not been tested for solubility in DMSO, however various sources report that it is soluble at 20 mg/mL.

      Helpful?

  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  6. What is the solution stability of Product E1024, Estradiol?

    1 answer

    1. Since this material is air sensitive, it is best to prepare solutions fresh.

      Helpful?

  7. What is the working range of Product E1024, Estradiol?

    1 answer

    1. For cell culture applications, the working range of this compound is 0.2 - 10 ng/mL.  For cell culture tested beta-estradiol, please refer to Sigma-Aldrich Prod. Nos. E2758 and E2257.

      Helpful?

  8. What is Product E1024, Estradiol, soluble in?

    1 answer

    1. It is soluble in ethanol, acetone, dioxane, and sparingly in vegetable oils.

      Helpful?

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