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E0162

Sigma-Aldrich

Carboxylesterase 1 isoform c human

recombinant, expressed in baculovirus infected BTI insect cells

Sinónimos:

Carboxylesterase 1 human, carboxylesterase, esterase

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1 VIAL
$498.00

$498.00

Fecha estimada de envío09 de abril de 2025DesdeSAINT LOUIS

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About This Item

Comisión internacional de enzimas:
3.1.1.1 (BRENDA, IUBMB)
Número CE:
232-773-7
Código UNSPSC:
12352204
NACRES:
NA.54

$498.00

Fecha estimada de envío09 de abril de 2025DesdeSAINT LOUIS

recombinante

expressed in baculovirus infected BTI insect cells

Nivel de calidad

200

Formulario

liquid

concentración

≥0.3 mg/mL

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

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Descripción general

Carboxylesterase 1 (CE1) is a member of a large multigene[1] carboxylesterase α,β-hydrolase family.[2] It is majorly expressed in the liver.[2] CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain.[2]

Aplicación

Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies.[3] It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.[4]

Acciones bioquímicas o fisiológicas

Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin.[2] They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs).[2] It also hydrolyzes aromatic and aliphatic esters[5] with preference to small alcohol groups and bulky acyl groups.[6] CE1 metabolizes drug esters and amides carbamates.[5] It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.[7]

Propiedades físicas

This product is offered in a volume of 0.5 mL.

Definición de unidad

One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Danger

Frases de peligro

H334

Clasificaciones de peligro

Resp. Sens. 1

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000289828
0000289828
SLCR2423
SLCR2418
SLCP8058

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Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
Jihong Lian et al.
Protein & cell, 9(2), 178-195 (2017-07-06)
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro
Carboxylesterases: sources, characterization and broader applications
Sood S, et al.
Insight (American Society of Ophthalmic Registered Nurses), 1, 1-11 (2016)
Characterisation of plasmatic B-esterases in bottlenose dolphins (Tursiops truncatus) and their potential as biomarkers of xenobiotic chemical exposures.
Sol??, et al.
Environmental Pollution (Barking, Essex : 1987), 313, 120149-120149 (2022)
Montserrat Solé et al.
Environmental toxicology and pharmacology, 82, 103561-103561 (2020-12-12)
Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate
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