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E006

β-Carboline-3-carboxylic acid N-methylamide

Benzodiazepine receptor inverse agonist, solid

Sinónimos:

β-CCA methylamide, FG-7142, N-Methyl-β-carboline-3-carboxamide

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Tamaño de envaseSKUDisponibilidadPrecio
100 mg
Comprobar disponibilidad del carrito
$311.00
500 mg
Comprobar disponibilidad del carrito
$1,070.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C13H11N3O
Número CAS:
Peso molecular:
225.25
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:

$311.00


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Nombre del producto

β-Carboline-3-carboxylic acid N-methylamide,

form

solid

Quality Level

color

light tan

solubility

DMSO: >10 mg/mL, H2O: insoluble

SMILES string

CNC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C13H11N3O/c1-14-13(17)11-6-9-8-4-2-3-5-10(8)16-12(9)7-15-11/h2-7,16H,1H3,(H,14,17)

InChI key

QMCOPDWHWYSJSA-UHFFFAOYSA-N

Gene Information

human ... BZRAP1(9256)

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Este artículo
SML2372C2020A6226
form

solid

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

100

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble

solubility

DMSO: >10 mg/mL, H2O: insoluble

color

light tan

color

white to beige

color

yellow

color

white

Gene Information

human ... BZRAP1(9256)

Gene Information

-

Gene Information

-

Gene Information

mouse ... Cnr1(12801), Cnr2(12802)
rat ... Cnr1(25248)

Biochem/physiol Actions

Benzodiazepine inverse receptor agonist; potent anxiogenic agent.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Disclaimer

Solutions may be stored for several days at 4 °C.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Visite la Librería de documentos

Robert G Mair et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(52), 14293-14300 (2008-12-26)
The rostral intralaminar thalamic nuclei (ILn) are organized to activate pathways originating in medial prefrontal cortex (mPF) that mediate memory-guided responding during alert, wakeful states. Previous studies have shown that rostral ILn or mPF lesions produce deficits in delayed matching
Jee Hyun Kim et al.
Behavioral neuroscience, 123(3), 641-649 (2009-06-03)
A recent finding suggested that when extinction occurs shortly after acquisition, renewal of an extinguished fear response (fear-potentiated startle) to a light conditioned stimulus (CS) is diminished (Myers, Ressler, & Davis, 2006). The present study attempted to extend this finding
Lotte C Houtepen et al.
Physiology & behavior, 102(1), 105-109 (2010-09-11)
While anxiety models are often based on locomotor activity responses, the stress-induced hyperthermia (SIH) paradigm uses the autonomic stress response by measuring body temperature. The effects of putative anxiogenic compounds in the SIH paradigm are inconclusive in mice and have
Jodi L Lukkes et al.
Physiology & behavior, 107(5), 719-725 (2012-05-16)
Previous studies have found that adolescent social isolation of rats can lead to an increased anxiety state during adulthood, while chronic anxiety states are associated with dysregulated local GABAergic inhibition within the basolateral amygdala (BL). Therefore, we investigated the effects
Sabrina F Lisboa et al.
The international journal of neuropsychopharmacology, 13(9), 1163-1173 (2010-07-01)
The ventral portion of the medial prefrontal cortex (vMPFC) has been related to the expression of contextual fear conditioning. This study investigated the possible involvement of CB1 receptors in this aversive response. Male Wistar rats were submitted to a contextual

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DISCOVER Bioactive Small Molecules for Neuroscience

Número de artículo de comercio global

SKUGTIN
E006-100MG04061832556413
E006-500MG04061832556420

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