D8946

DMH1

Name: DMH1
Brand: SIGMA
Price: 243 USD
Availability: InStock

≥98% (HPLC), powder, BMP inhibitor

Sinónimos:

4-[6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline

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5 MG

$243.00

25 MG

$1,020.00

$243.00

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Fórmula empírica (notación de Hill):

C₂₄H₂₀N₄O

Número CAS:

1206711-16-1

Peso molecular:

380.44

UNSPSC Code:

51111800

PubChem Substance ID:

329798883

NACRES:

NA.77

MDL number:

MFCD18384963

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Nombre del producto

DMH1, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

light yellow to orange

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC(C)OC(C=C1)=CC=C1C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3

InChI

1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3

InChI key

JMIFGARJSWXZSH-UHFFFAOYSA-N

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Este artículo	SML1535	SML1832	475949
Sigma-Aldrich D8946 DMH1	Sigma-Aldrich SML1535 DMH2	Sigma-Aldrich SML1832 DDR1 Inhibitor 7rh	Sigma-Aldrich 475949 MPS1 Inhibitor, NMS-P715
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 1 mg/mL, clear	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 10 mg/mL, clear, colorless
storage condition desiccated	storage condition -	storage condition -	storage condition OK to freeze, protect from light

General description

DMH1 stimulates neurogenesis of human-induced pluripotent stem cells (hiPSCs) and suppresses the growth and metastasis of lung cancer. It blocks cellular autophagy responses.

Application

DMH1 has been used for bone morphogenetic protein (BMP) inhibition.

Biochem/physiol Actions

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor.

DMH1 is a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH1 is a dorsomorphin analogue that exclusively targets the BMP but not the VEGF pathway.

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

0000471709

0000412938

0000381283

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¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Convergent evolution of bilaterian nerve cords.

José M Martín-Durán et al.

Nature, 553(7686), 45-50 (2017-12-14)

It has been hypothesized that a condensed nervous system with a medial ventral nerve cord is an ancestral character of Bilateria. The presence of similar dorsoventral molecular patterns along the nerve cords of vertebrates, flies, and an annelid has been

BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity.

Richard H Row et al.

eLife, 7 (2018-06-08)

The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs)

Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.

Mylah Villacorte et al.

Development (Cambridge, England), 143(11), 1958-1970 (2016-04-14)

Thyroid follicles, the functional units of the thyroid gland, are delineated by a monolayer of thyrocytes resting on a continuous basement membrane. The developmental mechanisms of folliculogenesis, whereby follicles are formed by the reorganization of a non-structured mass of non-polarized

Kwang Bo Jung et al.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 32(1), 111-122 (2017-09-01)

Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system is needed for visualizing the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here

DMH1 (4-[6-(4-isopropoxyphenyl) pyrazolo [1, 5-a] pyrimidin-3-yl] quinoline) inhibits chemotherapeutic drug-induced autophagy

Sheng Y, et al.

Acta Pharmaceutica Sinica. B, 5(4), 330-336 (2015)

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Número de artículo de comercio global

SKU	GTIN
D8946-25MG	04061833218419
D8946-5MG	04061833590096

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DMH1