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D7159

Sigma-Aldrich

2′,3′-Dideoxycytidine 5′-triphosphate sodium salt

≥90% (HPLC)

Sinónimos:

ddCTP

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About This Item

Fórmula empírica (notación de Hill):
C9H16N3O12P3
Número de CAS:
132619-66-0
Peso molecular:
451.16
MDL number:
MFCD00717536
UNSPSC Code:
12352202
PubChem Substance ID:
24894086

biological source

synthetic (organic)

assay

≥90% (HPLC)

form

powder

solubility

water: 1 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

[Na+].NC1=NC(=O)N(C=C1)[C@H]2CC[C@@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)O2

InChI

1S/C9H16N3O12P3.Na/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16;/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16);/q;+1/p-1/t6-,8+;/m0./s1

InChI key

LOOMQRBEBYCFPP-QDOHZIMISA-M

Application

Complexes of ddCTP with DNA polymerase β were studied by x-ray crystallography, with implications for inhibitory activity against HIV reverse transcriptase.

Biochem/physiol Actions

Inhibitor of DNA polymerase I-catalyzed chain elongation.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl
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BMC genomics, 15, 429-429 (2014-06-06)
Bacteroides fragilis is a Gram-negative anaerobe that is normally a human gut commensal; it comprises a small percentage of the gut Bacteroides but is the most frequently isolated Bacteroides from human infections. Identification of the essential genes necessary for the
Michal R Szymanski et al.
The EMBO journal, 34(14), 1959-1970 (2015-06-10)
The human DNA polymerase gamma (Pol γ) is responsible for DNA replication in mitochondria. Pol γ is particularly susceptible to inhibition by dideoxynucleoside-based inhibitors designed to fight viral infection. Here, we report crystal structures of the replicating Pol γ-DNA complex
Nutjaree Jeenduang et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 36-43 (2015-01-17)
Cardiovascular disease (CVD) is one of the major causes of death worldwide. Numerous genetic risk factors in lipid metabolism, including mutations of LDLR, APOB, and PCSK9, as well as polymorphisms of CETP and APOE, have been found to associate with

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