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MilliporeSigma

D6288

Sigma-Aldrich

6α,9α-Difluoroprednisolone 21-acetate 17-butyrate

≥98%

Sinónimos:

Difluprednate

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About This Item

Fórmula empírica (notación de Hill):
C27H34F2O7
Número de CAS:
Peso molecular:
508.55
EC Number:
MDL number:
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77

sterility

non-sterile

assay

≥98%

form

powder

solubility

chloroform: 50 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

SMILES string

CCCC(=O)O[C@@]1(CC[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C(=O)COC(C)=O

InChI

1S/C27H34F2O7/c1-5-6-23(34)36-26(22(33)14-35-15(2)30)10-8-17-18-12-20(28)19-11-16(31)7-9-24(19,3)27(18,29)21(32)13-25(17,26)4/h7,9,11,17-18,20-21,32H,5-6,8,10,12-14H2,1-4H3/t17-,18-,20-,21-,24-,25-,26-,27-/m0/s1

InChI key

WYQPLTPSGFELIB-JTQPXKBDSA-N

Gene Information

human ... NR3C1(2908)

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Mahmoud Tawfik KhalafAllah et al.
BMJ open, 9(11), e026752-e026752 (2019-11-05)
Topical steroids are the cornerstone in controlling the inflammation after cataract surgery. Prednisolone acetate and difluprednate are the two main products for this purpose. However, it is unclear which one should be used in terms of effectiveness and safety. Systematic
Masazumi Yamaguchi et al.
International journal of pharmaceutics, 301(1-2), 121-128 (2005-07-19)
Preparation of oil-in-water (o/w) type lipid emulsion is one of the approaches to formulate drugs that are poorly water-soluble but can be dissolved in the oil phase of the emulsions. A synthetic glucocorticoid medicine, difluprednate (DFBA), is a water-insoluble compound.
Eric D Donnenfeld et al.
Journal of cataract and refractive surgery, 47(2), 158-164 (2020-09-15)
To evaluate the safety and efficacy of a nepafenac punctal plug delivery system (N-PPDS) after cataract surgery. Three U.S. clinical sites. Prospective, multicenter, randomized (2:1), parallel-arm, double-masked, placebo-controlled, phase II pilot study. Fifty-six subjects (aged older than 22 years) with
Eric J Sigler et al.
Retina (Philadelphia, Pa.), 34(2), 237-246 (2013-07-25)
To describe the clinical and histopathologic characteristics of inflammatory deposits occurring within intermediate duration postoperative perfluoro-n-octane (PFO) for inferior retinal detachment repair. Prospective interventional case series of consecutive patients with inferior retinal detachment treated with intermediate duration postoperative vitreous cavity
Shin-ichi Yasueda et al.
Journal of pharmaceutical and biomedical analysis, 30(6), 1735-1742 (2002-12-18)
A specific and sensitive method for the determination for difluprednate (DFBA) and its metabolite (deacetylated DFBA, DFB) in aqueous humor was developed. DFBA and DFB were initially absorbed on a Pinkerton-type column, then analyzed by high-performance liquid chromatography using a

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