D5321

D36 hydrate

≥98% (HPLC)

• Sinónimos: 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• Fórmula empírica (notación de Hill): C₂₁H₂₄N₂O₂ · xH₂O
• Número de CAS: 1228184-64-2
• Peso molecular: 336.43 (anhydrous basis)
• MDL number: MFCD16875421
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798803

Propiedades

• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• InChI key: ZERKAKHVUQMJPW-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable