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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Sinónimos:

DCMB, LY-78335

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About This Item

Fórmula empírica (notación de Hill):
C8H9Cl2N · HCl
Número de CAS:
39226-94-3
Peso molecular:
226.53
MDL number:
MFCD00055225
UNSPSC Code:
12352202
PubChem Substance ID:
24278157

form

solid

color

white

solubility

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

SMILES string

Cl[H].CC(N)c1cccc(Cl)c1Cl

Gene Information

human ... PNMT(5409)

Biochem/physiol Actions

PNMT inhibitor.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number

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B A Adler et al.
Endocrinology, 113(4), 1431-1438 (1983-10-01)
Results from previous investigations have suggested an important role for central epinephrine (EPI) systems in mediating the stimulatory effects of ovarian hormones on LH release in ovariectomized female rats. The purpose of these experiments was 1) to test whether selective
M Kuboia et al.
Neuropsychobiology, 33(3), 132-137 (1996-01-01)
This study examines the in vivo effects of 2,3-dichloro-alpha-methylbenzylamine (DCMB), a centrally active phenylethanolamine-N-methyltransferase (PNMT) inhibitor, on alpha 2-adrenoceptors. Sixty-six rats received either DCMB, SKF29661, the peripheral PNMT inhibitor, at a dose of 50 mg/kg or saline intraperitoneally. To examine
alpha 2 Adrenoreceptor affinity of some inhibitors of norepinephrine N-methyltransferase.
R E Toomey et al.
Life sciences, 29(24), 2467-2472 (1981-12-14)
S P Kalra
Neuroendocrinology, 40(2), 139-144 (1985-02-01)
Adult female rats were implanted with permanent cannulae in the third ventricle of the brain and allowed to recover regular 4-day estrous cycles. They received intrajugular cannulae on the morning of proestrus and later between 12.00-13.00 h catecholamines - norepinephrine
L C Terry et al.
The Journal of clinical investigation, 69(1), 104-112 (1982-01-01)
Catecholamines are postulated to regulate growth hormone (GH) secretion by their influence on the release of two hypothalamic substances, somatostatin, which inhibits GH release, and GH-releasing factor, as yet unidentified. Extensive pharmacologic studies in man and animals indicate a stimulatory
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