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Key Documents

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D033

Sigma-Aldrich

(+)-Butaclamol hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C25H31NO · HCl
Número de CAS:
55528-07-9
Peso molecular:
397.98
MDL number:
MFCD00082307
UNSPSC Code:
12352200
PubChem Substance ID:
24278400
NACRES:
NA.77

form

powder

Quality Level

100

optical activity

[α]27/D +222° in methanol(lit.)

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL, clear

SMILES string

Cl[H].[H][C@@]12C[C@@](O)(CCN1C[C@@]3([H])c4ccccc4CCc5cccc2c35)C(C)(C)C

InChI

1S/C25H31NO.ClH/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25;/h4-10,21-22,27H,11-16H2,1-3H3;1H/t21-,22-,25-;/m0./s1

InChI key

QZRUMKUMFJJARD-AAJWHBHYSA-N

Gene Information

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

Application

(+)-Butaclamol hydrochloride has been used as a dopamine receptor blocker in:
  • dissected brain sections
  • striatum of Parkinson′s disease specimens
  • human embryonic kidney cells (HEK293 cells)
  • mice striatal tissue

Biochem/physiol Actions

(+)-Butaclamol is a dopamine receptor antagonist and is an active enantiomer.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Miriam E Bocarsly et al.
Cell reports, 29(5), 1147-1163 (2019-10-31)
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol. Here, we show that this association is conserved in mice and demonstrate
Shoma Sato et al.
The Journal of physiology, 596(12), 2447-2461 (2018-04-17)
Synaptic potentiation in Drosophila is observed at cholinergic synapses between antennal lobe (AL) and mushroom body (MB) neurons in the adult brain; however, depression at the AL-MB synapses has not yet been identified. By ex vivo Ca2+ imaging in an
Seeman
Pharmacological Reviews, 32, 229-229 (1981)
P J Pauwels et al.
British journal of pharmacology, 134(1), 88-97 (2001-08-28)
1. Antipsychotic drugs may mediate their therapeutic effects not only by preventing the binding of dopamine but also by decreasing the propensity of the dopamine receptor to assume an active R* state. Ligand-mediated activation and blockade of the recombinant human
Kimberly Regna et al.
BMC developmental biology, 16(1), 15-15 (2016-05-18)
Insect metamorphosis relies on temporal and spatial cues that are precisely controlled. Previous studies in Drosophila have shown that untimely activation of genes that are essential to metamorphosis results in growth defects, developmental delay and death. Multiple factors exist that
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