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C8661

Sigma-Aldrich

Cobalt(II) chloride hexahydrate

BioReagent, suitable for cell culture, suitable for insect cell culture

Sinónimos:

Cobaltous chloride hexahydrate

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25 G
$42.10
100 G
$142.00

$42.10

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25 G
$42.10
100 G
$142.00

About This Item

Fórmula lineal:
CoCl2 · 6H2O
Número de CAS:
7791-13-1
Peso molecular:
237.93
EC Number:
231-589-4
MDL number:
MFCD00149652
UNSPSC Code:
12352207
PubChem Substance ID:
24893093
NACRES:
NA.71

$42.10

En stockDetalles

Solicitar un pedido a granel

vapor pressure

40 mmHg ( 0 °C)

Quality Level

300

product line

BioReagent

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

SMILES string

O.O.O.O.O.O.Cl[Co]Cl

InChI

1S/2ClH.Co.6H2O/h2*1H;;6*1H2/q;;+2;;;;;;/p-2

InChI key

GFHNAMRJFCEERV-UHFFFAOYSA-L

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Application

  • Synthesis, Characterization, and Biological Activities of Novel Vanadium(IV) and Cobalt(II) Complexes: Investigates the synthesis of novel cobalt(II) complexes and their potential biological applications, particularly emphasizing their bioactive properties in various cellular models (Damena T, Zeleke D, Desalegn T, et al. 2022. ACS Omega).

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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International journal of biological sciences, 15(3), 587-597 (2019-02-13)
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Yuan Zhang et al.
Clinica chimica acta; international journal of clinical chemistry, 489, 203-211 (2017-12-11)
Accumulated data indicate that placental hypoxia is implicated in the pathogenesis of preeclampsia (PE). Tight junction (TJ) is important structure that sustains normal placental barrier function, its dysregulation under hypoxia has been observed. This study was designed to explore hypoxia-induced
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Can C8661 be used in normoxia to induce hypoxia?

    1 answer

    1. CoCl2 is generally known to replace Fe2+ that binds to prolyl hydroxylase (PHD), which degrades hypoxia-inducible factor‑1α (HIF-1a) under normoxic conditions. This binding blocks the activity of PHD and subsequently upregulates the level of HIF-1a to simulate hypoxic conditions.

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