C7863

Anti-Csk antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Número MDL: MFCD01633277
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: IgG fraction of antiserum
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: buffered aqueous solution
• mol peso: antigen 50 kDa
• reactividad de especies: human, rat
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using rat spleen; microarray: suitable; western blot: 1:2,000 using a whole cell extract of human Jurkat cell line and a cytosolic fraction of embryonic rat brain
• Nº de acceso UniProt: P41240
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CSK(1445) ; mouse ... Csk(12988) ; rat ... Csk(315707)

Descripción

Descripción general

Csk is a widely expressed non-receptor tyrosine kinase that consists of a catalytic domain, as well as SH2 and SH3 domains. This kinase phosphorylates the C-terminal tail of Src-family protein tyrosine kinases (SFKs) and subsequently inhibits SFKs. As SFKs have been associated carcinogenesis, Csk may have implications in cancer therapeutics
Anti-Csk antibody is specific for human and rat Csk. The product may also react with mouse Csk. In immunoblotting, staining of Csk is specifically inhibited with the Csk immunizing peptide (rat, amino acids 433-450).

Inmunógeno

peptide corresponding to amino acids 433-450 at the C-terminus of rat Csk. This sequence is highly conserved in human and mouse.

Aplicación

Anti-Csk antibody is suitable for use in western blot (1:2,000 using whole cell extracts of human Jurkat cell line and cytosolic fractions of embryonic rat brain). The product may also be used for microarray and immunohistochemistry (1:200 using formalin-fixed, paraffin-embedded sections of rat spleen).

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.