C7055
Monoclonal Anti-Calmodulin antibody produced in mouse
clone 2D1+6D4+1F11, ascites fluid
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About This Item
Número MDL:
Código UNSPSC:
12352203
Productos recomendados
origen biológico
mouse
conjugado
unconjugated
forma del anticuerpo
ascites fluid
tipo de anticuerpo
primary antibodies
clon
2D1+6D4+1F11, monoclonal
contiene
15 mM sodium azide as preservative
reactividad de especies
Dictyostelium discoideum, bovine, rat, chicken
técnicas
microarray: suitable
western blot: 1:100 using a bovine brain calmodulin preparation
isotipo
IgG1
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
rat ... Calm1(24242)
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Especificidad
These antibodies are directed against different epitopes within the calmodulin molecule.
Inmunógeno
A preparation of purified calmodulin from Dictyostelium discoideum conjugated to KLH.
Aplicación
Monoclonal Anti-Calmodulin antibody produced in mouse is suitable for microarray and western blotting at a dilution of 1:100 using a bovine brain calmodulin preparation.
Acciones bioquímicas o fisiológicas
Calmodulin 1 is a protein encoded by the CALM1 gene in humans. It is one of the most well characterized proteins and is used as a model system for calcium binding and large-scale protein conformational changes. Acts as a sensor protein that takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. It binds calcium ions during induction of intracellular signaling and is involved in silencing of calcium signal through activation of plasma membrane Ca2+-ATPase (directly) or SERCA pump (indirectly). Calmodulin may affect various channels like voltage gated calcium channels (VGCCs), transient receptor potential channels (TRPCs), NMDA receptors and calcium channels dependent on cyclic nucleotides or in endoplasmic reticulum.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
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Petri Kursula
Acta crystallographica. Section D, Biological crystallography, 70(Pt 1), 24-30 (2014-01-15)
Calmodulin is one of the most well characterized proteins and a widely used model system for calcium binding and large-scale protein conformational changes. Its long central helix is usually cut in half when a target peptide is bound. Here, two
Jesús Argueta et al.
International journal of molecular sciences, 23(5) (2022-03-11)
Melatonin (MEL) is a pleiotropic indolamine that reaches multiple intracellular targets. Among these, MEL binds to calmodulin (CaM) with high affinity. In presence of Ca2+, CaM binds to CaM-dependent kinase II (CaMKII). The Ca2+-CaM/CaMKII pathway regulates a myriad of brain
Aline Domínguez-Alonso et al.
International journal of molecular sciences, 16(1), 1907-1927 (2015-01-21)
Melatonin (MEL), the main product synthesized by the pineal gland, stimulates early and late stages of neurodevelopment in the adult brain. MEL increases dendrite length, thickness and complexity in the hilar and mossy neurons of hippocampus. Dendrite formation involves activation
Elzbieta Rebas et al.
Postepy biochemii, 58(4), 393-402 (2012-01-01)
Calmodulin (CaM) is a sensor protein, which takes part in calcium-dependent signaling, regulating processes like growth, differentiation, proliferation and motility. Calmodulin binds calcium ions during induction of intracellular signaling. It is also involved in silencing of calcium signal through activation
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