C6303

Calphostin C

From microbial (Cladosporium cladosporioides), ≥90% (HPLC), protein kinase C inhibitor, powder

• Sinónimos: UCN-1028c
• Fórmula empírica (notación de Hill): C₄₄H₃₈O₁₄
• Número CAS: 121263-19-2
• Peso molecular: 790.76
• UNSPSC Code: 12352200
• PubChem Substance ID: 24892857
• NACRES: NA.77
• MDL number: MFCD00133155

Propiedades

• Nombre del producto: Calphostin C from Cladosporium cladosporioides, ≥90% (HPLC), powder
• biological source: microbial (Cladosporium cladosporioides)
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• color: red to brown
• solubility: DMF: 1 mg/mL, DMSO: 1 mg/mL, ethanol: 1 mg/mL
• storage temp.: −20°C
• SMILES string: COc1cc(O)c2C(=O)C(OC)=C(CC(C)OC(=O)Oc3ccc(O)cc3)c4c5C(CC(C)OC(=O)c6ccccc6)=C(OC)C(=O)c7c(O)cc(OC)c(c57)c1c24
• InChI: 1S/C44H38O14/c1-20(56-43(50)22-10-8-7-9-11-22)16-25-31-32-26(17-21(2)57-44(51)58-24-14-12-23(45)13-15-24)42(55-6)40(49)34-28(47)19-30(53-4)36(38(32)34)35-29(52-3)18-27(46)33(37(31)35)39(48)41(25)54-5/h7-15,18-21,45-47H,16-17H2,1-6H3
• InChI key: SRJYZPCBWDVSGO-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Highly specific inhibitor of protein kinase C (IC₅₀ = 50 nM); requires light for activation. At higher concentrations (100 nM or greater), it has been shown to inhibit cell proliferation and induce apoptosis in vitro.

Features and Benefits

This compound is featured on the Phospholipase D and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)