C4187
Cyanoborohydride Coupling Buffer
Sinónimos:
Coupling buffer
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500 ML
$262.65
1 L
$477.00
$262.65
Precio de catálogo$309.00Ahorre 15 %Web-Only Promotion
Disponible para envío el11 de abril de 2025Detalles
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500 ML
$262.65
1 L
$477.00
About This Item
Código UNSPSC:
12161700
NACRES:
NA.56
$262.65
Precio de catálogo$309.00Ahorre 15 %Web-Only Promotion
Disponible para envío el11 de abril de 2025Detalles
Productos recomendados
Formulario
liquid
idoneidad de la reacción
reagent type: reductant
técnicas
affinity chromatography: suitable
aplicaciones
life science and biopharma
temp. de almacenamiento
2-8°C
Categorías relacionadas
Aplicación
A ready-to-use reagent used to couple amine ligands to aldehyde functional groups. The coupling buffer reaction is a reductive amination of the intermediate Schiff′s base to a stable C−N bond.
Cyanoborohydride Coupling Buffer has been used:
- in coupling reactions between amines and glutaraldehyde[1]
- to reduce hydrazone bond to a stable hydrazide bond[2]
- as a component in oligonucleotide reaction mixture for coverslips functionalization[3]
Cyanoborohydride Coupling Buffer is used in affinity chromatography, protein chromatography, activated/functionalized matrices and synthetic reagents. Cyanoborohydride has been used to inform a safe and effective gene-transfer system targeting hepatocytes as well as to develop a method for targeted delivery of anticancer therapeutics to cancer cells in hypoxic areas.
Acciones bioquímicas o fisiológicas
Cyanoborohydride Coupling Buffer is a reagent suitable for reductive amination processes, that contributes to transformation of simple alcohols into more complex amines.[4][5] It is used in the conversion of Schiff base, by reducing it, to form a secondary amine without affecting aldehyde groups on the support.[6]
Componentes
0.02 M sodium phosphate, pH 7.5, containing 0.2 M sodium chloride and 3.0 g/L sodium cyanoborohydride
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral - Aquatic Chronic 2
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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V S Hornsey et al.
Journal of immunological methods, 93(1), 83-88 (1986-10-23)
For coupling proteins to Sephacryl gels periodate oxidation of these gels was investigated as an alternative method to cyanogen bromide activation. Optimum conditions were studied with respect to periodate concentration, time of oxidation, pH and type of coupling buffer, concentration
Handbook of Affinity Chromatography (2005)
Hai-mei Hu et al.
Journal of biomaterials science. Polymer edition, 23(5), 677-695 (2011-03-08)
A non-viral gene-delivery system has been used to deliver plasmid DNA into specific cell types because of its safety and ease of manufacture. Receptor-mediated gene transfer is currently a promising gene-delivery technique. To specifically target genes to asialoglycoprotein receptor of
Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination
Bhattacharyya S, et al.
Tetrahedron Letters, 44(27), 4957-4960 (2003)
Christopher A Holden et al.
International journal of nanomedicine, 5, 25-36 (2010-02-18)
Tumors frequently contain hypoxic regions that result from a shortage of oxygen due to poorly organized tumor vasculature. Cancer cells in these areas are resistant to radiation- and chemotherapy, limiting the treatment efficacy. Macrophages have inherent hypoxia-targeting ability and hold
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