C3285

Complement C6 from human serum

80% (SDS-PAGE), >300,000 C6H50 units/mg protein

• Número CAS: 80295-56-3
• UNSPSC Code: 12352202
• MDL number: MFCD00130843

Propiedades

• assay: 80% (SDS-PAGE)
• specific activity: >300,000 C6H50 units/mg protein
• concentration: 1 mg/mL in PBS, pH 7.2
• UniProt accession no.: P13671
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... C6(729)

Descripción

General description

Complement C6 is one of five complement cascade proteins that are incorporated into the lytic terminal complement complex. It is over 33% homologous with C7, including all 56 cysteine residues; C6 and C7 share the arrangement of LDL-receptor class A and B modules, the thrombospondin type I module at the C-terminus, and the two short consensus repeat modules.

The mature protein consists of 913 amino acid residues preceded by a 21-residue signal sequence.

Application

Complement C6 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). It has been shown that complement C6 and the MAC are crucial for the development of arthritis in osteoarthritis and gouty arthritis. This could serve as a therapeutic target area for suppression of joint inflammation.

Analysis Note

Functionally active by a sensitive hemolytic assay.

Other Notes

View more information on the complement pathway at www.sigma-aldrich.com/enzymeexplorer

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Información de seguridad

• Clase de almacenamiento: 12 - Non Combustible Liquids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable