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MilliporeSigma

C2211

Sigma-Aldrich

Z-Leu-Leu-Leu-al

≥90% (HPLC)

Sinónimos:

MG-132

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5 MG
$178.00

$178.00


Disponible para envío el04 de abril de 2025Detalles


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5 MG
$178.00

About This Item

Fórmula empírica (notación de Hill):
C26H41N3O5
Número de CAS:
Peso molecular:
475.62
Número MDL:
Código UNSPSC:
12352209
ID de la sustancia en PubChem:
NACRES:
NA.32

$178.00


Disponible para envío el04 de abril de 2025Detalles


Solicitar un pedido a granel

Nombre del producto

Z-Leu-Leu-Leu-al, ≥90% (HPLC)

Nivel de calidad

Ensayo

≥90% (HPLC)

Formulario

powder

color

white

solubilidad

DMSO: soluble

temp. de almacenamiento

−20°C

cadena SMILES

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

Clave InChI

TZYWCYJVHRLUCT-VABKMULXSA-N

Información sobre el gen

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

Aplicación

Z-Leu-Leu-Leu-al or MG132 has been used as a proteasome inhibitor.[1][2] It has also been used to test the ubiquitylation and sumoylation pathways in urchin embryos.[3]

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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Certificados de análisis (COA)

Lot/Batch Number

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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

An Inducible Retroviral Expression System for Tandem Affinity Purification Mass-Spectrometry-Based Proteomics Identifies Mixed Lineage Kinase Domain-like Protein (MLKL) as an Heat Shock Protein 90 (HSP90) Client*
Johannes W. Bigenzahn
Molecular and Cellular Proteomics (2016)
Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin
Nathalie Oulhen
Developmental Biology (2016)
Proteasome inhibitors: from research tools to drug candidates
Alexei F.Kisselev
Chemistry and Biology, 8(8), 739-758 (2001)
Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-? levels in brain
Benjamin W
Journal of Neurochemistry (2016)
Vaino K. Hopsu-Havu, Mikko Jarvinen, Heidrun Kirschke
Proteolysis in Cell Functions (1997)

Questions

1–5 of 5 Questions  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What is the solution stability of MG132, Product C2211, Z-Leu-Leu-Leu-al?

    1 answer
    1. This product can be stored in aliquots at -20°C for up to one month.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  5. How should Product C2211, Z-Leu-Leu-Leu-al, be dissolved?

    1 answer
    1. MG132 is soluble in DMSO or at 10 mg/mL in a chloroform:methanol solution (95:5). We test the solubility at 1 mg/mL in methanol.

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