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C1997

Sigma-Aldrich

CYM-5442

≥98% (HPLC)

Sinónimos:

2-(4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl amino) ethanol

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5 MG
$393.30
25 MG
$1,141.00

$393.30

Precio de catálogo$414.00
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5 MG
$393.30
25 MG
$1,141.00

About This Item

Fórmula empírica (notación de Hill):
C23H27N3O4
Número de CAS:
1094042-01-9
Peso molecular:
409.48
Número MDL:
MFCD12912402
Código UNSPSC:
12352211
ID de la sustancia en PubChem:
329774920
NACRES:
NA.77

$393.30

Precio de catálogo$414.00
Web-Only Promotion

Disponible para envío el04 de abril de 2025Detalles

Solicitar un pedido a granel

Ensayo

≥98% (HPLC)

Formulario

solid

solubilidad

DMSO: >5 mg/mL

temp. de almacenamiento

−20°C

cadena SMILES

CCOc1ccc(cc1OCC)-c2nc(no2)-c3cccc4C(CCc34)NCCO

InChI

1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3

Clave InChI

NUIKTBLZSPQGCP-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo through a hydrophobic pocket, separable from the orthosteric site of S1P binding that is headgroup dependent. This is a different site from those involved in the activities of other agonists such as FTY720 and SEW2871.
CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist that activates S1P1-dependent pathways in vitro and to levels of full efficacy in vivo.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
039K46072
039K46071
039K4607

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Román Blanco et al.
Experimental eye research, 164, 37-45 (2017-08-23)
We investigated the feasibility and efficacy of using a specific sphingosine 1-phosphate (S1P1) receptor agonist, CYM-5442, to slow or block retinal ganglion cell (RGC) loss in endothelin-1 (ET-1) induced RGC loss. A single intravitreal injection of ET-1 (20pmol/ul), a potent
Alena Chumanevich et al.
Mediators of inflammation, 2016, 1503206-1503206 (2016-02-18)
Mast cells (MC) are present in most vascularized tissues around the vasculature likely exerting immunomodulatory functions. Endowed with diverse mediators, resident MC represent first-line fine-tuners of local microenvironment. Sphingosine-1-phosphate (S1P) functions as a pluripotent signaling sphingolipid metabolite in health and
Emily Crowley et al.
The FEBS journal, 287(22), 4917-4932 (2020-03-05)
Autophagy plays a role in several human diseases, but each of the current methods to measure autophagy has significant drawbacks. ATG5 and ATG16L1 are regulators necessary for autophagy; therefore, drugs that inhibit the interaction of these proteins may be therapeutically
Xiaochen Wang et al.
Immunity, 56(1), 58-77 (2022-12-16)
Obesity-induced chronic liver inflammation is a hallmark of nonalcoholic steatohepatitis (NASH)-an aggressive form of nonalcoholic fatty liver disease. However, it remains unclear how such a low-grade, yet persistent, inflammation is sustained in the liver. Here, we show that the macrophage
Léa M M Costes et al.
PloS one, 9(7), e102211-e102211 (2014-07-11)
Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of the gastrointestinal tract. Secondary lymphoid organs

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