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C1368

Sigma-Aldrich

Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide

≥98% (HPLC), solid

Sinónimos:

Aurora Kinase Inhibitor III

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About This Item

Fórmula empírica (notación de Hill):
C21H18F3N5O
Número de CAS:
879127-16-9
Peso molecular:
413.40
MDL number:
MFCD09265250
UNSPSC Code:
12352200
PubChem Substance ID:
24724434

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

H2O: <2 mg/mL
DMSO: >7 mg/mL

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cccc(Nc2ccnc(Nc3cccc(NC(=O)C4CC4)c3)n2)c1

InChI

1S/C21H18F3N5O/c22-21(23,24)14-3-1-4-15(11-14)26-18-9-10-25-20(29-18)28-17-6-2-5-16(12-17)27-19(30)13-7-8-13/h1-6,9-13H,7-8H2,(H,27,30)(H2,25,26,28,29)

InChI key

RDTDWGQDFJPTPD-UHFFFAOYSA-N

Biochem/physiol Actions

ATP-competitive Aurora A kinase inhibitor with IC50 = 42 nM

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Pooja Mohan et al.
Oncotarget, 4(1), 80-93 (2013-01-19)
Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target
Igor Astsaturov et al.
Science signaling, 3(140), ra67-ra67 (2010-09-23)
Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes closely linked to therapeutic targets would be enriched for determinants of drug resistance. We developed
Mahendra K Singh et al.
Cancer research, 70(21), 8907-8916 (2010-10-14)
Elevated expression of the NEDD9/HEF1/Cas-L scaffolding protein promotes tumor cell invasion and metastasis in multiple cancer cell types. Conversely, generation of mammary tumors in the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyVT) genetic model is delayed by a
Qiong Zhang et al.
Journal of the American Chemical Society, 128(7), 2182-2183 (2006-02-16)
The epidermal growth factor receptor (EGFR) tyrosine kinase was one of the first receptor tyrosine kinases to be targeted for drug development by the pharmaceutical industry due to its ubiquitous overexpression in a variety of tumors. Despite the validation of
Ming Shen Tham et al.
Nature communications, 15(1), 371-371 (2024-01-09)
Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA's role in regulating renal cyst development we conditionally deleted the gene in mouse models of Autosomal Dominant PKD (ADPKD)
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