B3313
Bicyclol
≥98% (HPLC)
Sinónimos:
4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C19H18O9
Número CAS:
Peso molecular:
390.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
COC(=O)c1cc(OC)c2OCOc2c1-c3c(CO)cc(OC)c4OCOc34
InChI
1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3
InChI key
KXMTXZACPVCDMH-UHFFFAOYSA-N
General description
Bicyclol has anti-inflammatory properties and enhances the prognosis of kidney transplantation. It is involved in the removal of reactive oxygen species and modulates cytokine secretion.
Biochem/physiol Actions
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C.
Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Effect of Bicyclol tablets on drug induced liver injuries after kidney transplantation
Shang W, et al.
Open Medicine : A Peer-Reviewed, Independent, Open-Access Journal, 12(1), 62-69 (2017)
Qinge Ma et al.
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