B0806
Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Sinónimos:
Anti-β-Site APP Cleaving Enzyme
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Acerca de este artículo
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB
Citations:
13
Servicio técnico
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Permítanos ayudarlebiological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 70 kDa
species reactivity
human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
technique(s)
microarray: suitable, western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BACE1(23621)
Categorías relacionadas
General description
BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) is known as β-secretase. BACE-1 is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. It constitutes the predominant β-secretase activity in human brain tissue.
Immunogen
synthetic peptide corresponding to the C-terminus of human BACE-1 (amino acids 485-501).
Application
Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Overexpression of β-site APP cleaving enzyme (BACE-1) leads to increased β-secretase activity while displaying appropriate cleavage site specificity for amyloid precursor protein (APP).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Clase de almacenamiento
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Marcus O W Grimm et al.
International journal of molecular sciences, 17(11) (2016-11-02)
One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with
Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms
Grimm MOW, et al.
Test, 286(16), 14028-14039 (2011)
S Prasad Gabbita et al.
PloS one, 10(10), e0137305-e0137305 (2015-10-06)
Cytokines such as TNFα can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is thought to impair phagocytosis and has been described in Alzheimer's Disease (AD). Neuroinflammation can be perpetuated by a cycle of
Marcus O W Grimm et al.
Scientific reports, 10(1), 9164-9164 (2020-06-10)
The vanilloid capsaicin is a widely consumed spice, known for its burning and "hot" sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence tau-pathology. Beside these positive effects, little is known about its
Tatjana L Rothhaar et al.
TheScientificWorldJournal, 2012, 141240-141240 (2012-05-02)
Lipids play an important role as risk or protective factors in Alzheimer's disease (AD). Previously it has been shown that plasmalogens, the major brain phospholipids, are altered in AD. However, it remained unclear whether plasmalogens themselves are able to modulate
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| B0806-.2ML | 04061838102416 |
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