B019

Phenoxybenzamine hydrochloride

Name: Phenoxybenzamine hydrochloride
Brand: SIGMA
Price: 137 USD
Availability: InStock

≥97%, powder

Sinónimos:

N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

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250 MG

$137.00

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Fórmula empírica (notación de Hill):

C₁₈H₂₂ClNO · HCl

Número CAS:

63-92-3

Peso molecular:

340.29

NACRES:

NA.77

PubChem Substance ID:

24277760

UNSPSC Code:

12352116

EC Number:

200-569-7

MDL number:

MFCD00055152

Assay:

≥97%

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥97%

form

powder

color

white

solubility

H₂O: slightly soluble, alcohol: soluble, propylene glycol: soluble

originator

Wellspring

storage temp.

2-8°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)

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Este artículo	SML0667	C8417	SML0036
Sigma-Aldrich B019 Phenoxybenzamine hydrochloride	Sigma-Aldrich SML0667 PF-429242 dihydrochloride	Sigma-Aldrich C8417 N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride	Sigma-Aldrich SML0036 Procarbazine hydrochloride
form powder	form powder	form solid	form powder
assay ≥97%	assay ≥98% (HPLC)	assay ≥98%	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 200	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
solubility H₂O: slightly soluble, propylene glycol: soluble, alcohol: soluble	solubility H₂O: 15 mg/mL, clear	solubility H₂O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble	solubility DMSO: ≥18 mg/mL
originator Wellspring	originator -	originator -	originator -

Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302,H351

pcodes

P201 - P301 + P312 + P330 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Is dexmedetomidine the agent of choice in the resection of pheochromocytoma?

Harsha V Polavarapu et al.

The American surgeon, 78(3), E127-E128 (2012-04-25)

Selective α1-adrenoceptor antagonist (controlled release tablets) in preoperative management of pheochromocytoma.

Yu Zhu et al.

Endocrine, 38(2), 254-259 (2010-11-04)

The objective of this article is to evaluate the efficacy of Doxazosin Mesylate Controlled Release Tablets for preoperative treatment of patients with pheochromocytoma. Between 2003 and 2008, 67 patients with confirmed diagnoses of pheochromocytoma were enrolled in this study. According

Standardized management improves outcomes after the Norwood procedure.

Chandra Srinivasan et al.

Congenital heart disease, 4(5), 329-337 (2009-09-11)

In the past decade, many advances in the care of patients undergoing the Norwood procedure (NP) have been reported, but management remains nonstandardized at many institutions. We studied the impact of a standardized management protocol for neonates undergoing NP. Care

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration.

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The Journal of pharmacology and experimental therapeutics, 347(3), 645-659 (2013-09-21)

The kinetics of drug-receptor interactions can profoundly influence in vivo and in vitro pharmacology. In vitro, the potencies of slowly associating agonists may be underestimated in assays capturing transient signaling events. When divergent receptor-mediated signaling pathways are evaluated using combinations

In vivo evidence for the generation of a glucocorticoid receptor-heat shock protein-90 complex incapable of binding hormone by the calmodulin antagonist phenoxybenzamine.

Y M Ning et al.

Molecular endocrinology (Baltimore, Md.), 10(1), 14-23 (1996-01-01)

The glucocorticoid receptor (GR) is a ligand-regulated transcription factor whose ability to bind hormone is thought to be dependent on association with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the

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SKU	GTIN
B019-250MG	04061833419571

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