AV40278

Anti-FUS antibody produced in rabbit

affinity isolated antibody

• Sinónimos: Anti-FUS-CHOP, Anti-FUS1, Anti-Fusion (involved in t(12;16) in malignant liposarcoma), Anti-TLS
• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• Formulario: lyophilized powder
• mol peso: 53 kDa
• reactividad de especies: mouse, rabbit, rat, human, bovine
• concentración: 0.5 mg - 1 mg/mL
• técnicas: immunohistochemistry: suitable; western blot: suitable
• Nº de acceso NCBI: NP_004951
• Nº de acceso UniProt: P35637
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... FUS(2521)

Descripción

Descripción general

Fused in sarcoma (FUS); translocated in LipoSarcoma (TLS) is a component of a fusion pro-oncogene resulting from a chromosomal translocation seen in liposarcomas. FUS/TLS belongs to a sub-family of RNA binding proteins that interacts with RNA, ssDNA, and dsDNA. FUS/TLS is involved in unique functions in mRNA processing and transport, transcriptional regulation and maintenance of genomic stability. FUsed in sarcoma (FUS); Translocated in LipoSarcoma (TLS) is a multifunctional protein implicated in a wide range of cellular processes, including transcription and mRNA processing, as well as in both cancer and neurological disease. Mutations in the fused in sarcoma (FUS) gene are linked to a form of familial amyotrophic lateral sclerosis (ALS), ALS6.

Especificidad

Anti-FUS/TLS polyclonal antibody reacts with chicken, bovine, human, mouse, and rat FUsed in sarcoma/translocated in LipoSarcoma proteins.

Inmunógeno

The immunogen for anti-FUS antibody: synthetic peptide derected towards the N terminal of human FUS

Aplicación

Anti-FUS/TLS polyclonal antibody is used to tag FUsed in sarcoma/translocated in LipoSarcoma proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the possible roles of FUsed in sarcoma/translocated in LipoSarcoma proteins in transcription and mRNA processing and amyotrophic lateral sclerosis, ALS6

Secuencia

Synthetic peptide located within the following region: MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGY

Forma física

Lyophilized from PBS buffer with 2% sucrose

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable