AV32030

Anti-MyCN antibody produced in rabbit

IgG fraction of antiserum

• Sinónimos: Anti-v-Myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 50 kDa
• species reactivity: dog, horse, bovine, mouse, human
• concentration: 0.5 mg - 1 mg/mL
• technique(s): western blot: suitable
• NCBI accession no.: NP_005369
• UniProt accession no.: P04198
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... MYCN(4613)

Descripción

General description

MyCN is a basic helix-loop-helix protein that has been implicated neuroblastomas. Studies have linked childhood neuroblastomas with MyCN amplifications to caspase 8 supression.
Rabbit Anti-MyCN antibody recognizes rat, canine, mouse, and human MyCN.

Immunogen

Synthetic peptide directed towards the C terminal region of human MYCN

Application

Rabbit Anti-MyCN antibody can be used for western blot applications at a concentration of 2.5μg/ml.

Biochem/physiol Actions

MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. It is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas

Sequence

Synthetic peptide located within the following region: EDAPPQKKIKSEASPRPLKSVIPPKAKSLSPRNSDSEDSERRRNHNILER

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable