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A4634

Sigma-Aldrich

2-Amino-6-chloropurine riboside

≥95%

Sinónimos:

(−)-2-Amino-6-chloropurine riboside, 6-Chloroguanine riboside

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About This Item

Fórmula empírica (notación de Hill):
C10H12ClN5O4
Número de CAS:
2004-07-1
Peso molecular:
301.69
EC Number:
217-905-3
MDL number:
MFCD00005735
UNSPSC Code:
41106305
PubChem Substance ID:
24890889

assay

≥95%

form

powder

mp

165-167 °C (dec.) (lit.)

solubility

water: 10 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Nc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1

InChI

1S/C10H12ClN5O4/c11-7-4-8(15-10(12)14-7)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1

InChI key

TXWHPSZYRUHEGT-UUOKFMHZSA-N

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Application

2-Amino-6-chloropurine riboside is used in the biosynthesis of mutagenic and prodrug nucleosides such as 2′-deoxy-2-(p-nitrophenyl)-adenosine and 6-deoxyacyclovir and of 6-arylthio analogues.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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A Matsuda et al.
Nucleic acids symposium series, 17(17), 141-143 (1986-01-01)
The reaction of 2-amino-6-chloropurine riboside with i-amyl nitrite in benzene in the presence of Cu2O, followed by treatment with NH3/MeOH gave 2-phenyladenosine (1). The crude sample of 1 was found to be mutagenic to bacteria (Salmonella typhimurium TA 98 and
Takayoshi Torii et al.
Nucleosides, nucleotides & nucleic acids, 25(4-6), 655-665 (2006-07-15)
A key compound, 2-amino-6-chlor-9-(2,3-dideoxy-3-fluoro-beta-D-erythro-pentofuranosyl)puine, was prepared from 2-amino-6-chloropurine riboside in 5 steps, then subjected to the nucleophilic displacement with benzenethiols to afford 6-arylthio congeners. These compounds showed a similar anti-HBV effect to that of 2',3' dideoxy-3'-fluoroguanosine.
Alicja Stachelska-Wierzchowska et al.
Molecules (Basel, Switzerland), 24(8) (2019-04-19)
Etheno-derivatives of guanine, O6-methylguanine, and isoguanine were prepared and purified using standard methods. The title compounds were examined as potential substrates of purine-nucleoside phosphorylases from various sources in the reverse (synthetic) pathway. It was found that 1,N2-etheno-guanine and 1,N6-etheno-isoguanine are
J T Kusmierek et al.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 41(10), 701-707 (1987-11-01)
D.c. polarography of 2-amino-6-chloropurine in aqueous medium over a broad pH range revealed two diffusion waves, the first of which corresponds to reduction of the C(6)-Cl bond, leading to formation of 2-aminopurine in high yield. Condensation of the sodium salt

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