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A2754

Sigma-Aldrich

Adenosine 5′-diphosphate sodium salt

bacterial, ≥95% (HPLC)

Sinónimos:

ADP sodium salt, ADP

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100 MG
$54.80
500 MG
$70.50
1 G
$122.00
5 X 1 G
$483.00

$54.80

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100 MG
$54.80
500 MG
$70.50
1 G
$122.00
5 X 1 G
$483.00

About This Item

Fórmula empírica (notación de Hill):
C10H15N5O10P2
Número de CAS:
20398-34-9
Peso molecular:
427.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24890690
NACRES:
NA.51

$54.80

En stockDetalles

biological source

bacterial

Quality Level

300

assay

≥95% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

[Na].Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(O)=O)C(O)C3O

InChI

1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChI key

XTWYTFMLZFPYCI-KQYNXXCUSA-N

Gene Information

human ... HSP90AA1(3320) , P2RY1(5028)

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General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:
  • as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
  • in the preparation of stock solution for a mito stress test.
  • as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
  • as a platelet agonist to stimulate platelet aggregation.[1]

Storage Class

11 - Combustible Solids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000406586
0000394607
0000394608
0000392901
0000392902

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Scientific reports, 7(1), 17170-17170 (2017-12-08)
Given the rising incidence of non-alcoholic fatty liver disease (NAFLD) in both adults and children, the development of a non-invasive diagnostic method for assessing disease progression to non-alcoholic steatohepatitis (NASH) has become an important research goal. Currently available non-invasive imaging
Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo
Jin RC, et al.
Circulation, 123(18), 1963-1973 (2011)
Klaus H Nielsen et al.
RNA (New York, N.Y.), 15(1), 67-75 (2008-11-27)
The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion
Richard C Jin et al.
Circulation, 123(18), 1963-1973 (2011-04-27)
Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment. A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke
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Protocolos

LC/MS Analysis of Nucleotides SeQuant® ZIC®-cHILIC – Effect of pH

ZIC®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

Questions

1–6 of 6 Questions  

  1. Is product A2754 FDA approved for use in testing patient samples (Platelet aggregation/function testing) at this time?

    1 answer

    1. No, the product A2754 is not FDA approved for testing patient samples for platelet aggregation/function testing at this time.

      Helpful?

  2. I see that the  molecular weight for Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754, on the website does not include sodium, water and solvent content. Why is that?

    1 answer

    1. The amount of sodium, water and solvent for ADP sodium salt will vary from lot to lot.  The specific lot information can be found on the certificate of analysis located at our website. To obtain the "true" molecular weight (so that one can calculate the molarity of a solution), the sodium, water and solvent amount must be added to the molecular weight listed on the website.

      Helpful?

  3. What are the spectral properties of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. The millimolar extinction coefficient of a pH 7 solution of ADP sodium salt is 15.4 at the absorbance maximum wavelength of 259 nm.

      Helpful?

  4. What is the solubility of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. ADP sodium salt is soluble in water at a concentration of 50 mg/mL.

      Helpful?

  5. What is the solution stability of Adenosine 5'-diphosphate (ADP) sodium salt, Product A2754?

    1 answer

    1. ADP sodium salt is stable in solution for several months when stored at pH 7 and at -20 °C.  When a solution is stored at pH 7 and 4 °C, the solution is stable for several days. It is unstable in acid.

      Helpful?

  6. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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