A2487

Cotrimoxazole, Ready Made Solution

100 mg/mL in DMSO

• Sinónimos: Trimethoprim-Sulfamethoxazole, TMP-SMX
• Fórmula empírica (notación de Hill): C₁₄H₁₈N₄O₃ · 5 C₁₀H₁₁N₃O₃S
• Número de CAS: 8064-90-2
• Peso molecular: 1556.71
• Número MDL: MFCD00242808
• Código UNSPSC: 51102829
• NACRES: NA.85

Propiedades

• Formulario: liquid
• Nivel de calidad: 200
• concentración: 100 mg/mL in DMSO
• color: colorless to faint yellow
• espectro de actividad antibiótica: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites
• Modo de acción: DNA synthesis | interferes
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• cadena SMILES: [S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N
• InChI: 1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)
• Clave InChI: WZRJTRPJURQBRM-UHFFFAOYSA-N

Descripción

Aplicación

Cotrimoxazole has been used as an antimicrobial agent.[1][2]

Acciones bioquímicas o fisiológicas

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Envase

1ml

Nota de preparación

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Otras notas

Keep container tightly closed in a dry and well-ventilated place.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Warning
• Frases de peligro: H361fd,H412
• Consejos de prudencia: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Clasificaciones de peligro: Aquatic Chronic 3 - Repr. 2
• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable