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A2487

Cotrimoxazole

Name: Cotrimoxazole
Brand: SIGMA
Price: 654 USD
Availability: InStock

Ready Made Solution, 100 mg/mL in DMSO

Sinónimos:

Trimethoprim-Sulfamethoxazole, TMP-SMX

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Talla/SKU	Disponibilidad	Precio
1 mL	Disponible para enviar HOYdesdeMILWAUKEE	$872.00 $654.00

Acerca de este artículo

Fórmula empírica (notación de Hill):

C₁₄H₁₈N₄O₃· 5 C₁₀H₁₁N₃O₃S

Número CAS:

8064-90-2

Peso molecular:

1556.71

MDL number:

MFCD00242808

UNSPSC Code:

51102829

NACRES:

NA.85

$654.00

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Propiedades

Quality Segment

200

form

liquid, ready-to-use solution

concentration

100 mg/mL in DMSO

color

colorless to faint yellow

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi, parasites

mode of action

DNA synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

[S](=O)(=O)(Nc4n[o]c(c4)C)c3ccc(cc3)N.Nc1nc(c(cn1)Cc2cc(c(c(c2)OC)OC)OC)N

InChI

1S/C14H18N4O3.C10H11N3O3S/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2-6H,11H2,1H3,(H,12,13)

InChI key

WZRJTRPJURQBRM-UHFFFAOYSA-N

Descripción

Application

Cotrimoxazole has been used as an antimicrobial agent.

Biochem/physiol Actions

Cotrimoxazole, a combination of trimethoprim and sulfamethoxazole, interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase (DHFR) which inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF), resulting in an antimicrobial effect. Sulfamethoxazole interferes with the synthesis of nucleic acids in sensitive microorganisms by blocking the conversion of p-aminobenzoic acid to the coenzyme dihydrofolic acid. The net effect of these actions is to inhibit thymidine synthesis which prevents bacterial DNA synthesis.

Packaging

1ml

Preparation Note

prepared using a 1:5 mixture of trimethoprim:sulfamethoxazole

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

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Este artículo	SBR00024	D3072	P1189
Sigma-Aldrich A2487 Cotrimoxazole	Sigma-Aldrich SBR00024 Trimethoprim	Sigma-Aldrich D3072 Doxycycline Hydrochloride, Ready Made Solution	Sigma-Aldrich P1189 Polymyxin B ready made solution
description Ready Made Solution, 100 mg/mL in DMSO	description Ready Made Solution, 25 mg/mL in DMSO	description 100 mg/mL in DMSO, ≥95.0% (HPLC)	description Cell culture tested, 17 mg/mL in H₂O
mode of action DNA synthesis \| interferes	mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action protein synthesis \| interferes	mode of action -
antibiotic activity spectrum Gram-negative bacteria, fungi, parasites, Gram-positive bacteria	antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria	antibiotic activity spectrum Gram-negative bacteria, mycoplasma, Gram-positive bacteria, parasites	antibiotic activity spectrum -
Quality Level 200	Quality Level -	Quality Level 200	Quality Level 200
form liquid, ready-to-use solution	form ready-to-use solution, liquid	form liquid	form liquid
concentration 100 mg/mL in DMSO	concentration 25 mg/mL in DMSO	concentration 100 mg/mL in DMSO	concentration 17 mg/mL in H₂O
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

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Pictogramas

GHS08

Palabra de advertencia

Warning

Códigos de peligro

H361fd,H412

Indicaciones de precaución

P202 - P273 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Aquatic Chronic 3 - Repr. 2

Clase de almacenamiento

12 - Non Combustible Liquids

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)