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A2169

Sigma-Aldrich

3′-Azido-3′-deoxythymidine

≥98% (HPLC), powder, reverse transcriptase inhibitor

Sinónimos:

AZT, Azidothymidine, ZDV, Zidovudine

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25 MG
$88.35
100 MG
$275.50
250 MG
$534.00
1 G
$1,710.00

$88.35

Precio de catálogo$93.00Ahorre 5 %

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25 MG
$88.35
100 MG
$275.50
250 MG
$534.00
1 G
$1,710.00

About This Item

Fórmula empírica (notación de Hill):
C10H13N5O4
Número de CAS:
30516-87-1
Peso molecular:
267.24
Beilstein:
3595791
Número MDL:
MFCD00006536
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278143
NACRES:
NA.77

$88.35

Precio de catálogo$93.00Ahorre 5 %

En stockDetalles

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Nombre del producto

3′-Azido-3′-deoxythymidine, ≥98% (HPLC)

Ensayo

≥98% (HPLC)

Formulario

powder

mp

113-115 °C (lit.)

solubilidad

H2O: 50 mg/mL

temp. de almacenamiento

−20°C

cadena SMILES

CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O

InChI

1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3,6-8,16H,2,4H2,1H3,(H,12,17,18)/t6-,7+,8+/m0/s1

Clave InChI

HBOMLICNUCNMMY-XLPZGREQSA-N

Información sobre el gen

human ... HIVE1(3095)
mouse ... Slc29a1(63959)

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Aplicación

3′-Azido-3′-deoxythymidine has been used as the reverse transcriptase inhibitor to inhibit the viral genome integration[1] and as an antimicrobial agent to evaluate its anti-Salmonella activity.[2]

Acciones bioquímicas o fisiológicas

Azidothymidine (AZT), a thymidine analogue, is a reverse transcriptase inhibitor against the HIV-1 virus. Azidothymidine has been shown to decrease CRISPR-mediated homology-directed repair (HDR) efficiency.
Reverse transcriptase inhibitor active against HIV-1 virus.

Características y beneficios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H341,H351

Clasificaciones de peligro

Carc. 2 - Muta. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
MKCW0371
MKCW5948
MKCS1355
MKCR8766
MKCQ4508

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Questions

  1. For the use of this product in cell culture, what would be the best conditions for making stock solutions. Solvent, concentration, filtering, storage temp etc.?

    1 answer

    1. Unfortunately, this product has not been tested for cell culture applications. This compound is soluble at 50 mg/mL in water. For use in cell culture, the stock solution should be filter sterilized. Syringe filter product SLGVR33RS may be of interest. The pharmaceutical literature suggests that the stock solution is stable for 1 day at room temperature and 2 days if refrigerated.

      See the link below to a publication (page 3) regarding the stability of AZT in solution:
      https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019910s041lbl.pdf

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