The half life of this inhibitor has not been determined.
Seleccione un Tamaño
1 MG
$59.91
5 MG
$266.00
$59.91
Precio de catálogo$63.20Ahorre 5 %Disponible para envío el01 de abril de 2025Detalles
Seleccione un Tamaño
Cambiar Vistas
1 MG
$59.91
5 MG
$266.00
About This Item
Fórmula empírica (notación de Hill):
C26H24N2O4
Número de CAS:
Peso molecular:
428.48
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.77
$59.91
Precio de catálogo$63.20Ahorre 5 %Disponible para envío el01 de abril de 2025Detalles
Productos recomendados
origen biológico
synthetic (organic)
Ensayo
>95% (HPLC)
Formulario
powder
mol peso
Mw 428.5
solubilidad
DMSO: 10 mg/mL, clear, colorless to greenish-yellow
temp. de almacenamiento
−20°C
cadena SMILES
N(c2ccc(cc2)c3ccc(cc3)C(=O)[C@H]4[C@@H](CCC4)C(=O)O)C(=O)Nc1ccccc1
InChI
1S/C26H24N2O4/c29-24(22-7-4-8-23(22)25(30)31)19-11-9-17(10-12-19)18-13-15-21(16-14-18)28-26(32)27-20-5-2-1-3-6-20/h1-3,5-6,9-16,22-23H,4,7-8H2,(H,30,31)(H2,27,28,32)/t22-,23-/m1/s1
Clave InChI
BOZRFEQDOFSZBV-DHIUTWEWSA-N
Aplicación
Acciones bioquímicas o fisiológicas
Diacylglycerol acyltransferase (DGAT-1) inhibitor; IC50 7 to 24 nM
The diacylglycerol acyltransferase (DGAT) 1 inhibitor A922500 was shown to effectively reduce postprandial serum triglyceride levels in rodents at concentrations of 0.03, 0.3 and 3 mg/kg. These results suggest A922500 may have beneficial effects in reducing the risk of cardiovascular disease. [5]
Forma física
A922500 is supplied as a crystalline solid.
Nota de preparación
A stock solution may be made by dissolving the A922500 in the solvent of choice. A922500 is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis
Leiguez E, et al.
Mediators of Inflammation, 2018 (2018)
Lipid droplets induced by secreted phospholipase A2 and unsaturated fatty acids protect breast cancer cells from nutrient and lipotoxic stress
Jarc E, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1863(3), 247-265 (2018)
A specific lipid metabolic profile is associated with the epithelial mesenchymal transition program
Giudetti AM, et al.
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(3), 344-357 (2019)
Andrew J King et al.
European journal of pharmacology, 637(1-3), 155-161 (2010-04-14)
Postprandial serum triglyceride concentrations have recently been identified as a major, independent risk factor for future cardiovascular events. As a result, postprandial hyperlipidemia has emerged as a potential therapeutic target. The purpose of this study was two-fold. Firstly, to describe
Increased triacylglycerol-Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid
Lovsletten NG, et al.
PLoS ONE, 13(11), e0208048-e0208048 (2018)
-
What is the half life of the inhibitor
1 answer-
Helpful?
-
-
Hello, in your description sector, it says this product can be dissolved in ethanol. However I have checked other sources that say A922500 is insoluble in ethanol. Could you clarify this for me?
1 answer-
This product is tested for solubility in DMSO at 10 mg/mL. The material is less soluble in ethanol at approximately 200 ug/mL. In addition, this compound may be dissolved in dimethylformamide at 20 mg/mL.
Helpful?
-
Active Filters
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico
