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75351

Oligomicina A

≥99% (HPLC)

Oligomycin A

Sinónimos:

MCH 32

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A ustedes/SKUDisponibilidadPrecio
5 mg

Disponible para enviar HOYdesdeMILWAUKEE

$220.00

Acerca de este artículo

Fórmula empírica (notación de Hill):
C45H74O11
Número CAS:
Peso molecular:
791.06
UNSPSC Code:
51102829
NACRES:
NA.76
PubChem Substance ID:
EC Number:
209-437-3
Beilstein/REAXYS Number:
5702132
MDL number:

$220.00


Disponible para enviar HOYDetalles


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Quality Segment

assay

≥99% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: soluble

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CCC1CCC2OC3(CC[C@@H](C)C(C[C@H](C)O)O3)[C@H](C)C(OC(=O)\C=C\[C@@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@H](C)C(=O)[C@@](C)(O)[C@H](O)[C@@H](C)C\C=C\C=C\1)[C@H]2C

InChI

1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15+,21-18+/t25-,26-,27+,28+,29+,30-,31+,32+,33-,34?,35?,36?,38+,40-,41?,42-,44+,45?/m1/s1

InChI key

MNULEGDCPYONBU-VVXVDZGXSA-N

General description

Estructura química: macrólido

Application

La oligomicina se utilizó para inhibir la síntesis de sacarosa y la translocación de 14C en las hojas de girasol, para estudiar la resistencia a antibióticos y las respuestas de los quimiorreceptores carotídeos al O2 y el CO2 en el gato. Inhibe el crecimiento de Rhodotorula glutinis, Aspergillus niger y otros hongos.[1]

Biochem/physiol Actions

La oligomicina bloquea la fosforilación oxidativa y la cadena de transporte de electrones inhibiendo la ATP sintasa (ATPasa) mitocondrial ligada a la membrana y bloqueando el canal de protones (bomba, subunidad FO).

Packaging

Frasco de vidrio sin fondo. El contenido está en el interior del cono fundido insertado.

Other Notes

Mantenga el recipiente herméticamente cerrado y en un lugar bien ventilado. Consérvese en un lugar seco. Consérvese en un lugar seco.

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Este artículo
O487649545559983
antibiotic activity spectrum

fungi

antibiotic activity spectrum

fungi

antibiotic activity spectrum

-

antibiotic activity spectrum

Gram-positive bacteria

mode of action

enzyme | inhibits

mode of action

enzyme | inhibits

mode of action

-

mode of action

protein synthesis | interferes

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

200

assay

≥99% (HPLC)

assay

≥90% total oligomycins basis (HPLC)

assay

≥90% (mixture of A, B, and C isomers, HPLC)

assay

≥90% (HPLC)

form

powder

form

powder

form

powder

form

powder

solubility

DMSO: soluble

solubility

-

solubility

-

solubility

-


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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Questions

1–5 of 5 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. For how long does the product remain stable once dissolved, aliquoted and stored at -20°C?

    1 answer
    1. Storage of stock solutions at -20°C is stable for 1 month.

      Helpful?

  4. Does this product contain thimerosal or any mercury-containing preservatives?

    1 answer
    1. This is a pure product, not containing any preservative or thimerosal.

      Helpful?

  5. What's it's solubility in dmso

    1 answer
    1. This product is not tested for solubility in DMSO, however other Oligomycin products have been found to be soluble at in DMSO at 50 mg/ml.

      Helpful?

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