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69125

Resorufin methyl ether

Name: Resorufin methyl ether
Brand: SIGMA

suitable for fluorescence, ≥98.0% (HPLC)

Sinónimos:

7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O⁷-Methylresorufin

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About This Item

Fórmula empírica (notación de Hill):

C₁₃H₉NO₃

Número de CAS:

5725-89-3

Peso molecular:

227.22

Beilstein/REAXYS Number:

209529

MDL number:

MFCD00037663

UNSPSC Code:

12352200

PubChem Substance ID:

57652175

assay

≥98.0% (HPLC)

form

crystals

mp

≥220 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
alcohols: soluble

fluorescence

λ_ex 571 nm; λ_em 585 nm in dealkylase(lit.)

suitability

suitable for fluorescence

storage temp.

2-8°C

SMILES string

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

InChI key

KNYYMGDYROYBRE-UHFFFAOYSA-N

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Application

Used to differentiate isozymes of cytochrome P-450

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

90101

Ampliflu^™ Red

Sigma-Aldrich

R7017

Resazurin sodium salt

Sequencing and characterization of mixed function monooxygenase genes CYP1A1 and CYP1A2 of Mink (Mustela vison) to facilitate study of dioxin-like compounds.

Xiaowei Zhang et al.

Toxicology and applied pharmacology, 234(3), 306-313 (2008-12-02)

As part of an ongoing effort to understand aryl hydrocarbon receptor (AhR) mediated toxicity in mink, cDNAs encoding for CYP1A1 and the CYP1A2 mixed function monooxygenases were cloned and characterized. In addition, the effects of selected dibenzofurans on the expression

Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.

Nicholas E Hadjokas et al.

British journal of pharmacology, 136(3), 347-352 (2002-05-25)

1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular

Potential impact of steatosis on cytochrome P450 enzymes of human hepatocytes isolated from fatty liver grafts.

M Teresa Donato et al.

Drug metabolism and disposition: the biological fate of chemicals, 34(9), 1556-1562 (2006-06-10)

Liver grafts discarded for transplantation because of macrosteatosis can constitute a valuable source of human hepatocytes for in vitro metabolic and pharmacotoxicological studies or for therapeutic applications. A condition for using hepatocyte suspensions for these purposes is the preservation of

Alteration of the pharmacokinetics of theophylline by rutaecarpine, an alkaloid of the medicinal herb Evodia rutaecarpa, in rats.

Yune-Fang Ueng et al.

The Journal of pharmacy and pharmacology, 57(2), 227-232 (2005-02-22)

Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. To evaluate the pharmacokinetic

Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals.

D F Staskal et al.

Toxicological sciences : an official journal of the Society of Toxicology, 84(2), 225-231 (2005-01-22)

Dioxins have been shown to bind and induce rodent CYP1A2, producing a dose-dependent hepatic sequestration in vivo. The induction of CYP1A2 activity has been used as a noninvasive biomarker for human exposure to dioxins; while there is a consistent relationship

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