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30070

Sigma-Aldrich

Cysteamine

≥98.0% (RT)

Sinónimos:

β-Mercaptoethylamine, 2-Aminoethanethiol, 2-Mercaptoethylamine, Decarboxycysteine, MEA, Thioethanolamine

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About This Item

Fórmula lineal:
NH2CH2CH2SH
Número de CAS:
60-23-1
Peso molecular:
77.15
Beilstein/REAXYS Number:
635649
EC Number:
200-463-0
MDL number:
MFCD00008196
UNSPSC Code:
12352116
PubChem Substance ID:
57648397
NACRES:
NA.25

Quality Level

200

assay

≥98.0% (RT)

storage temp.

2-8°C

SMILES string

NCCS

InChI

1S/C2H7NS/c3-1-2-4/h4H,1-3H2

InChI key

UFULAYFCSOUIOV-UHFFFAOYSA-N

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Application

Cysteamine is suitable for use:
  • in the preparation of cysteamine modified gold nanoparticles (AuNP)
  • in the fabrication of SU-8 microrods, where in, the amine group of cysteamine reacts with the unreacted epoxide rings present on the surface of the particles, thereby opening it and forming a covalent bond
  • to enhance in vitro development of porcine oocytes matured and fertilized in vitro
  • in a study to demonstrate the depletion effect of cysteamine on cystinotic leucocyte granular fractions of cystine by disulphide interchange
  • as a radioprotector
  • to administer subcutaneously in rats to study its blocking effect on somatostatin secretion without modifying the pancreatic insulin or glucagon content
  • as a scavenger in electrophoretic gels (acetic acid/urea gels)

Biochem/physiol Actions

Cysteamine (β-mercaptoethylamine) depletes cystine from patient′s cells and there by regulates renal glomerular function and increases growth in them. Therefore, cysteamine is considered to be a potential therapeutic for nephropathic cystinosis.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Successful treatment of severe paracetamol overdosage with cysteamine.
L F Prescott et al.
Lancet (London, England), 1(7858), 588-592 (1974-04-06)
W A Gahl et al.
The Biochemical journal, 228(3), 545-550 (1985-06-15)
Cystinotic lysosome-rich leucocyte granular fractions, loaded with [35S]cystine, were exposed to different cystine-depleting agents. During a 30 min incubation at 37 degrees C, untreated cystinotic granular fractions lost negligible [35S]cystine when corrected for lysosome rupture. Granular fractions exposed to 0.1
R L Sorenson et al.
Diabetes, 32(4), 377-379 (1983-04-01)
Cysteamine (300 mg/kg) administered subcutaneously depletes pancreatic somatostatin to 36% of control levels, but does not alter pancreatic insulin or glucagon content. Although perfusion of pancreata from normal animals with glucose (300 mg/dl) markedly stimulated somatostatin release, pancreata from cysteamine-treated
Cysteamine therapy for children with nephropathic cystinosis
Gahl WA, et al.
The New England Journal of Medicine, 316(16), 971-977 (2018)
J Carmichael et al.
Cancer research, 47(4), 943-946 (1987-02-15)
Radiation survival curves were generated for V79 Chinese hamster and two human lung cancer cell lines (NCI-H460 and NCI-H249) with doubling times of 10, 20, and 85 h, respectively, using a standard clonogenic assay, a dye exclusion assay, and a
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