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Y0001601

Alfacalcidol for system suitability

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

1α-Hydroxyvitamin D3, 1α-Hydroxycholecalciferol, Alfacalcidol

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About This Item

Fórmula empírica (notación de Hill):
C27H44O2
Número de CAS:
Peso molecular:
400.64
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24

origen biológico

synthetic

grado

pharmaceutical primary standard

Agency

EP

Formulario

solid

fabricante / nombre comercial

EDQM

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

−20°C

cadena SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C

InChI

1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1

Clave InChI

OFHCOWSQAMBJIW-AVJTYSNKSA-N

Información sobre el gen

human ... VDR(7421)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

Synthetic vitamin D3 analog that is metabolized to 1,25-dihydroxycholecalciferol. Inhibits bone resorption and stimulates bone formation. Supresses parathyroid hormone secretion by bovine parathyroid cells.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

Pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Consejos de prudencia

Clasificaciones de peligro

Acute Tox. 1 Oral

Código de clase de almacenamiento

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Vitamin D and metabolites measurement by tandem mass spectrometry
van den Ouweland JMW, et al.
Reviews in Endocrine & Metabolic Disorders, 14(2), 159-184 (2013)
Siobhan O'Donnell et al.
Journal of bone and mineral metabolism, 26(6), 531-542 (2008-11-04)
Our objective was to conduct a systematic review on the benefits and harms of calcitriol and alfacalcidol in the reduction of fracture and fall risk. Randomized controlled trials (RCTs) comparing these agents to placebo or calcium and reporting fracture and
Noboru Kubodera
Mini reviews in medicinal chemistry, 9(12), 1416-1422 (2009-11-26)
Many readers may have only a vague idea about vitamin D. This is made complicated, in part, because it is also expressed with suffixes such as vitamin D(2) or vitamin D(3). Otherwise the prefix of "active" is also occasionally used.
Koji Nakamura et al.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 25(2), 288-295 (2015-01-09)
Removal of the ovaries is common during surgery for endometrial cancer. However, because loss of the ovaries can cause several health problems in patients, strategies for the prevention of such problems need to be established. Hence, we decided to conduct
Florent Richy et al.
Aging clinical and experimental research, 17(2), 133-142 (2005-06-28)
Alfacalcidol (1-alpha-hydroxyvitamin D3) is a non-endogenous analog of vitamin D which can bypass the renal and intestinal regulatory mechanisms that control the production of calcitriol (1,25-hydroxyvitamin D3, the active form of vitamin D, D-Hormone). Alfacalcidol may be metabolized into calcitriol

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