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S2155000

Sulfasalazine

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid, 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid, Salicylazosulfapyridine

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About This Item

Fórmula empírica (notación de Hill):
C18H14N4O5S
Número de CAS:
Peso molecular:
398.39
Beilstein/REAXYS Number:
356241
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:

API family

sulfasalazine

mp

260-265 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

OC(=O)c1cc(ccc1O)\N=N\c2ccc(cc2)S(=O)(=O)Nc3ccccn3

InChI

1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+

InChI key

NCEXYHBECQHGNR-QZQOTICOSA-N

Gene Information

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Sulfasalazine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Health hazardEnvironment

signalword

Danger

Hazard Classifications

Aquatic Chronic 2 - Carc. 2 - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2


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Greg L Plosker et al.
Drugs, 65(13), 1825-1849 (2005-08-24)
Sulfasalazine (salazosulfapyridine) [Azulfidine, Salazopyrin] is a well established disease-modifying antirheumatic drug (DMARD) used in the treatment of patients with rheumatoid arthritis. Clinical trials with sulfasalazine have used an array of measures of disease activity, such as the number of tender
Miscellaneous treatments, I: sulfasalazine and pentoxifylline: unapproved uses, dosages, or indications.
Ronni Wolf et al.
Clinics in dermatology, 20(5), 531-546 (2002-11-19)
Nail lesions in psoriatic arthritis: recovery with sulfasalazine treatment.
J C Gerster et al.
Annals of the rheumatic diseases, 61(3), 277-277 (2002-02-07)
Victoria Linares et al.
Expert opinion on drug safety, 10(2), 253-263 (2011-01-12)
Sulfasalazine (SASP) is a drug commonly used in the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease (CD) and rheumatoid arthritis (RA). A high incidence of side effects limits therapy with this drug. Getting a
Fabrice Michel et al.
Joint, bone, spine : revue du rhumatisme, 72(1), 82-85 (2005-02-01)
DRESS (Drug Rash with Eosinophilia and Systemic Symptoms) is a drug-induced hypersensitivity syndrome that can mimic malignant lymphoma. We report a case in a 63-year-old woman who had been on sulfasalazine for 2 months to treat rheumatoid arthritis. She was

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