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PHR1271

Supelco

3,4-Dihidroxi-L-fenilalanina

Levodopa

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

3-(3,4-Dihidroxifenil)-L-alanina, L-3-Hidroxitirosina, L-DOPA, Levodopa

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500 MG
$115.00

$115.00

Disponible para envío el10 de abril de 2025Detalles

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500 MG
$115.00

About This Item

Fórmula lineal:
(HO)2C6H3CH2CH(NH2)CO2H
Número de CAS:
59-92-7
Peso molecular:
197.19
Beilstein:
2215169
Número CE:
200-445-2
Número MDL:
MFCD00002598
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329823267
NACRES:
NA.24

$115.00

Disponible para envío el10 de abril de 2025Detalles

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grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to BP 213
traceable to Ph. Eur. L0400000
traceable to USP 1361009

familia API

levodopa

CofA

current certificate can be downloaded

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

276-278 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O

InChI

1S/C9H11NO4/c10-6(9(13)14)3-5-1-2-7(11)8(12)4-5/h1-2,4,6,11-12H,3,10H2,(H,13,14)/t6-/m0/s1

Clave InChI

WTDRDQBEARUVNC-LURJTMIESA-N

Información sobre el gen

human ... DRD3(1814)

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Descripción general

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Levodopa is a metabolic precursor of the neurotransmitter dopamine[1] and is widely used in the treatment of Parkinson′s disease.[2]

Aplicación

Levodopa may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations[3][4] using flow injection spectrophotometric method[3] and 1H nuclear magnetic resonance spectroscopy.[4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAC2957 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Referencia del producto
Descripción
Precios

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H315,H319,H335

Clasificaciones de peligro

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

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Certificados de análisis (COA)

Lot/Batch Number

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Parkinson's Disease and Related Disorders, 506(1), 97-104 (2006)
1H nuclear magnetic resonance spectroscopy analysis for simultaneous determination of levodopa, carbidopa and methyldopa in human serum and pharmaceutical formulations
Talebpour Z, et al.
Analytica Chimica Acta, 506(1), 97-104 (2004)
L H Marcolino-Júnior et al.
Journal of pharmaceutical and biomedical analysis, 25(3-4), 393-398 (2001-05-30)
A flow injection spectrophotometric procedure was developed for determining levodopa in tablets. The determination of this drug was carried out by reacting it with lead(IV) dioxide immobilized in polyester resin packed in a solid-phase reactor and the dopachrome yielded was
Handbook of Parkinson's Disease
Parkinson's Disease and Related Disorders, 506(4), 97-104 (2007)
A P de Jong et al.
Clinica chimica acta; international journal of clinical chemistry, 171(1), 49-61 (1988-01-15)
L-3-(3,4-Dihydroxyphenyl)alanine (DOPA) and its 3-O-methyl metabolite (OMD) were measured in plasma and cerebrospinal fluid by a new assay which combines N,O-acetylation of amino acids in aqueous media, preparation of pentafluorobenzyl esters under anhydrous conditions, and analysis by gas chromatography-electron capture
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. For how long should you store L-DOPA after elution?

    1 answer

    1. As a neat material stored at a refrigerated temperature and protected from light, levodopa is stable for at least 3 years. Levodopa is not stable in solution for long durations. According to peer-reviewed literature, levodopa degrades significantly in solution at ambient temperature over the course of 48 hours. The addition of a reducing agent such as ascorbate can prolong solution stability up to 72 hours. Refrigeration or freezing of the solution can significantly reduce levodopa degradation for up to 7 days. In general, it is recommended to prepare a solution of levodopa the day it is needed.

      Helpful?

  4. What is the best solvent that dissolves this product? To prepare the stock solution

    1 answer

    1. It is soluble in water (3 mg/ml), DMSO (<1 mg/ml at 25° C), and 0.5M HCl (50 mg/ml).

      Helpful?

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