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PHR1073

Supelco

1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Avobenzona, Butylmethoxydibenzoylmethane

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About This Item

Fórmula empírica (notación de Hill):
C20H22O3
Número de CAS:
70356-09-1
Peso molecular:
310.39
EC Number:
274-581-6
MDL number:
MFCD00210252
UNSPSC Code:
41116107
PubChem Substance ID:
329823096
NACRES:
NA.24

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

agency

traceable to USP 1045337

API family

avobenzone

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

environmental
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C

InChI

1S/C20H22O3/c1-20(2,3)16-9-5-14(6-10-16)18(21)13-19(22)15-7-11-17(23-4)12-8-15/h5-12H,13H2,1-4H3

InChI key

XNEFYCZVKIDDMS-UHFFFAOYSA-N

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General description

Avobenzone is an active sunscreen ingredient, used in sunscreen lotions and cosmetic formulations.[1]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Avobenzone may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography technique.[2]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3693 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Referencia del producto
Descripción
Precios

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

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Certificados de análisis (COA)

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Development and validation of a new RP-HPLC method for the simultaneous determination of hydroquinone, kojic acid, octinoxate, avobenzone, BHA and BHT in skin-whitening cream.
Galimany-Rovira F, et al.
Analytical Methods : Advancing Methods and Applications, 8(5), 1170-1180 (2016)
Virginie Lhiaubet-Vallet et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 9(4), 552-558 (2010-04-01)
In most sunscreens, the presence of two UV filters usually leads to synergistic effects regarding both the final performance and photostabilization of the active principles. However, this may also result in an accelerated decomposition if a photoreaction occurs between the
Jing Yang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 69(2), 605-612 (2008-01-30)
The objective of the present study was to determine the effects of hydroxypropyl-beta-cyclodextrin (HPCD) complexation on the transdermal penetration and photostability of a model ultraviolet A (UVA) absorber, butyl methoxydibenzoylmethane (avobenzone), and to determine the influence of complexation on in
Beatrice Albertini et al.
Journal of pharmaceutical sciences, 98(8), 2759-2769 (2008-12-11)
Solid lipid microparticles (SLMs) loaded with high amounts of the sunscreen agent, butyl methoxydibenzoylmethane (avobenzone) were prepared in order to reduce its photoinstability. The microparticles were produced, using carnauba wax as lipidic material and phosphatidylcholine as the surfactant, by the
Cecilia Paris et al.
Photochemistry and photobiology, 85(1), 178-184 (2008-08-05)
Novel sunscreens are required providing active protection in the UVA and UVB regions. On the other hand, there is an increasing concern about the photosafety of UV filters, as some of them are not sufficiently photostable. Avobenzone is one of
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