This product is not tested for use in research animals such as mice. But there certainly is precedence for its use by researchers in a mouse model:
1. https://pubmed.ncbi.nlm.nih.gov/32663612/
See Table 1.
2. https://pubmed.ncbi.nlm.nih.gov/37380774/
See Methods section.
O1008
Ácido oleico
Oleic acid
1 of 1 reviewers received a sample product or took part in a promotion
≥99% (GC)
Sinónimos:
Ácido 9Z-octadecenoico, ácido cis-oleico, Ácido cis-9-octadecenoico, Ácido elaínico
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1 G
$34.20
5 G
$95.50
25 G
$306.00
About This Item
Fórmula lineal:
CH3(CH2)7CH=CH(CH2)7COOH
Número de CAS:
Peso molecular:
282.46
Beilstein/REAXYS Number:
1726542
EC Number:
MDL number:
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.25
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biological source
plant (Sunflower)
Quality Level
vapor pressure
1 mmHg ( 176 °C)
assay
≥99% (GC)
form
viscous liquid
color
colorless to very faintly yellow
refractive index
n20/D 1.459 (lit.)
bp
194-195 °C/1.2 mmHg (lit.)
mp
13-14 °C (lit.)
solubility
H2O: insoluble (practically)
alcohol: soluble
benzene: soluble
chloroform: soluble
oil: soluble (fixed and volatile)
density
0.89 g/mL at 25 °C (lit.)
application(s)
life science and biopharma
lipidomics
functional group
oleic acid
lipid type
unsaturated FAs
shipped in
ambient
storage temp.
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCC(O)=O
InChI
1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-
InChI key
ZQPPMHVWECSIRJ-KTKRTIGZSA-N
Gene Information
human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584) , SOAT1(6646) , SOAT2(8435)
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General description
El ácido oleico (OA), un ácido graso no esencial, se clasifica como ácido graso monoinsaturado (MUFA) muy abundante en el aceite de oliva.[1] Se ha comunicado su eliminación cuantitativa de las mezclas de triglicéridos y glicéridos parciales.[2] El OA se utiliza ampliamente como tensioactivo para la estabilización de nanopartículas magnéticas. Se han preparado nanopartículas de magnetita monodispersas (7 y 19 nm) recubiertas con OA.[3]
Application
Se ha utilizado ácido oleico:
- para estudiar los efectos de los ácidos grasos sobre el cáncer gástrico (GC)[4]
- para inducir la formación de gotitas de lípidos en cultivo celular[5]
- como aditivo en la preparación de fluidos magnetorreológicos[6].
Biochem/physiol Actions
Se sabe que el ácido oleico mejora la función inmunitaria y la salud. El enriquecimiento alimentario con este ácido graso contribuye a la reducción de los niveles de colesterol, el riesgo de aterogénesis, la presión arterial y la respuesta injerto contra huésped. Se ha demostrado que el ácido oleico es beneficiosos para las enfermedades autoinmunitarias al exhibir acción antiinflamatoria. También mejora el estado del cáncer de mama.[1] El ácido oleico produce efectos fisiológicos como la activación de la proteína cinasa C en los hepatocitos, el desacoplamiento de la fosforilación oxidativa y la inhibición de la ATPasa estimulada con 2,4-dinitrofenol−. Esta acción puede invertirse agregando albúmina sérica.
Other Notes
Si desea más información sobre nuestra gama de productos bioquímicos, cumplimente este formulario.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
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THE STEREOSPECIFIC CONVERSION OF STEARIC ACID TO OLEIC ACID.
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Pan J, et al.
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Thakur MK and Sarkar C
IEEE Transactions on Magnetics, 56(5) (2020)
Oleic acid coating on the monodisperse magnetite nanoparticles.
Zhang L, et al.
Applied Surface Science, 253(5), 2611-2617 (2006)
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Journal of hepatology, 66(5), 962-977 (2016-12-17)
PARP1 is a key mediator of cellular stress responses and critical in multiple physiological and pathophysiological processes of cells. However, whether it is involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) remains elusive. We analysed PARP1 activity in
Artículos
Supplement cell culture systems with fatty acids for biomanufacturing heterologous proteins like monoclonal antibodies.
How the unsaturated fatty acid, oleic acid and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies.
Magnetic nanoparticles have attracted tremendous attention due to their novel properties and their potential applications in magnetic recording, magnetic energy storage and biomedicine.
DISCOVER Bioactive Small Molecules for Neuroscience
Protocolos
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Can be used in mice?
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How to store the product after opening the amplue?
1 answer-
The stability of this product in solution has not been determined. However, cell culture supplements containing Oleic acid, available as sterile solutions, are stored at 2-8°C and assigned a shelf life of 1 year. See the table below:
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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What solvent is used to resuspend oleic acid in this product?
1 answer-
This product is a neat or pure liquid that has not been diluted. The recommended solvents are ethanol, methanol, chloroform, and benzene. This information is listed in the 'PROPERTIES' section of the product page.
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What sort of packaging for the vial do you offer ?
1 answer-
The packaging varies according to the quanitity. The 1G package is in a 5 mL clear glass, flat bottom, sealed ampule. The 5G package is in a 10 mL clear glass, flat bottom, sealed ampule. The 25G package is in a 50 mL clear glass, flat bottom, sealed ampule.
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Hello, would OA be soluble in DMSO? Also, after diluting in solvent, how long can it be stored in -20?
1 answer-
Oleic acid is completely miscible with Dimethyl sulfoxide (DMSO) in all proportions. It is generally not recommended to store solutions of unsaturated fatty acids such as oleic acid, due to oxidation. But if the solution is stored under an inert gas (e.g., nitrogen gas or argon gas), that would extend the stability of the solution.
The exact amount of time that the solution is stable is undetermined. Evidence for instability of the solution would be a change in color (colorless to yellow, or yellow to dark yellow, or dark yellow to brown).
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How to sterilize pure oleic acid?
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This product can be sterilized by autoclaving. When diluted in medium or buffer to a working concentration, solutions can be filter-sterilized.
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hello, i would like to know please the concentration of oeic acid in this solution and in what solution we can dissolve it else than chloroform for exemple can we dissolve it in the water and heat (70°C) or in the BSA directly thank you
1 answer-
The solubility information is listed on the product detail page under the "Properties" section as follows:
H2O: insoluble (practically)
alcohol: soluble
benzene: soluble
chloroform: soluble
oil: soluble (fixed and volatile)The concentration for this product will be lot specific as purity changes with each batch. The concentration of this material can be calculated by the equation density x 1000, x purity percent divided by the molecular weight. For example, lot 0000216415 on the sample certificate of analysis will have a concentration of about 3.12 M
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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