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B3022

Supelco

Beclomethasone dipropionate

analytical standard, for drug analysis

Sinónimos:

9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

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About This Item

Fórmula empírica (notación de Hill):
C28H37ClO7
Número de CAS:
5534-09-8
Peso molecular:
521.04
Número CE:
226-886-0
Número MDL:
MFCD00135613
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329773210
NACRES:
NA.24

Nivel de calidad

200

Ensayo

≥99%

técnicas

HPLC: suitable
gas chromatography (GC): suitable

aplicaciones

forensics and toxicology
veterinary

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]12C

InChI

1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1

Clave InChI

KUVIULQEHSCUHY-XYWKZLDCSA-N

Información sobre el gen

human ... NR3C1(2908)

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Descripción general

Beclomethasone dipropionate belongs to the chemical class of chlorinated glucocorticoid diesters, well known for its use in the treatment of asthma due to its anti-inflammatory properties.

Aplicación

Beclomethasone dipropionate analytical standard can be used as follows:
  • Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method, combined with UV detection to determine beclomethasone dipropionate in nanocapsule suspensions
  • Simultaneous determination of beclomethasone dipropionate and ketoconazole in their bulk and combined cream formulations using UV-spectrophotometry and RP-HPLC based methods
  • Estimation of beclomethasone dipropionate and formoterol fumarate in their combined dosage forms by stability indicating RP-HPLC method coupled with UV detection
  • Combined analysis of beclomethasone dipropionate and formoterol fumarate dihydrate using two UV-spectrometric and one RP-HPLC based methods in bulk and their pharmaceutical dosage forms
  • Multi-residue analysis of 21 glucocorticoids in environmental samples by ultra-high performance liquid chromatography (UHPLC) and mass spectrometry (MS)

Otras notas

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictogramas

Health hazard
GHS08

Palabra de señalización

Warning

Frases de peligro

H361fd,H373

Clasificaciones de peligro

Repr. 2 - STOT RE 2

Órganos de actuación

Adrenal gland,Immune system,Bone

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000434136
0000434135
0000434132
0000434132
0000434135

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Quick Review of Pharmacology null
Jessica K Roberts et al.
The Journal of pharmacology and experimental therapeutics, 345(2), 308-316 (2013-03-21)
Inhaled glucocorticoids, such as beclomethasone dipropionate (BDP), are the mainstay treatment of asthma. However, ≈ 30% of patients exhibit little to no benefit from treatment. It has been postulated that glucocorticoid resistance, or insensitivity, is attributable to individual differences in
Tiago Nunes et al.
Journal of Crohn's & colitis, 7(3), 183-191 (2012-07-13)
IBD is a chronic and relapsing inflammatory disorder of the gut that demands long-lasting treatment targeting both flare-up periods and maintenance of remission. Oral systemic steroids have been used to induce remission in patients with active IBD for over 50
Julius H van Bavel et al.
Allergy and asthma proceedings, 33(5), 386-396 (2012-10-03)
An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of
Gail Hayward et al.
The Cochrane database of systematic reviews, 8(8), CD008116-CD008116 (2012-08-17)
The common cold is a frequent illness, which, although benign and self-limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit. Corticosteroids are an effective treatment in other
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