917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride

≥95%

• Sinónimos: Semi-flexible linker for PROTAC^® development
• Fórmula empírica (notación de Hill): C₁₂H₁₈ClNO
• Número de CAS: 1187927-60-1
• Peso molecular: 227.73
• MDL number: MFCD11506185
• UNSPSC Code: 12352200

Propiedades

• Quality Level: 100
• assay: ≥95%
• form: powder
• reaction suitability: reagent type: linker
• functional group: hydroxyl
• storage temp.: 2-8°C
• SMILES string: OCC1=CC=C(C2CCNCC2)C=C1.Cl
• InChI: 1S/C12H17NO.ClH/c14-9-10-1-3-11(4-2-10)12-5-7-13-8-6-12;/h1-4,12-14H,5-9H2;1H
• InChI key: JSCRYCUDRVBGRN-UHFFFAOYSA-N

Descripción

Application

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable