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63176

Sigma-Aldrich

6-Maleimidohexanoic acid

≥98.0% (HPLC)

Sinónimos:

6-Maleimidocaproic acid, N-Maleoyl-6-aminocaproic acid, N-(5-Carboxypentyl)maleimide

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About This Item

Fórmula empírica (notación de Hill):
C10H13NO4
Número de CAS:
55750-53-3
Peso molecular:
211.21
Beilstein/REAXYS Number:
1532405
MDL number:
MFCD00043140
UNSPSC Code:
12352005
PubChem Substance ID:
329759803
NACRES:
NA.25

Quality Level

200

assay

≥98.0% (HPLC)

mp

86-91 °C

storage temp.

room temp

SMILES string

OC(=O)CCCCCN1C(=O)C=CC1=O

InChI

1S/C10H13NO4/c12-8-5-6-9(13)11(8)7-3-1-2-4-10(14)15/h5-6H,1-4,7H2,(H,14,15)

InChI key

WOJKKJKETHYEAC-UHFFFAOYSA-N

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Application

6-Maleimidohexanoic acid may be used as a spacer in the construction of drug and other types of bioconjugates. 6-Maleimidohexanoic acid is used with N-hydroxysuccinimide ester as a bifunctional cross-linking reagent.
Probe for thiol groups (SH-groups) in membrane proteins.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H335

Hazard Classifications

Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
0000303158
0000303157
0000305217
0000296080
0000296075

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Shinya Kida et al.
Chemical & pharmaceutical bulletin, 55(4), 685-687 (2007-04-06)
6-maleimidohexanoic acid N-hydroxysuccinimide ester has been used widely for preparation of enzyme immunoconjugates as a unique heterobifunctional cross-linking reagent. Its heterobifunctional reactivity is good, but its ester portion hydrolyzes easily in the presence of water. Several 6-maleimidohexanoic acid active esters
Mitsuko Maeda et al.
Bioorganic & medicinal chemistry letters, 15(3), 621-624 (2005-01-25)
The adenovirus vector is a promising carrier for the efficient transfer of genes into cells via the coxackie-adenovirus receptor (CAR) and integrins (alphavbeta3 and alphavbeta5). The clinical use of the adenovirus vector remains problematic however. Successful administration of this vector
Ralph Rahme et al.
Journal of neurosurgery, 121(6), 1354-1358 (2014-09-27)
The role of endovascular therapy in patients with acute ischemic stroke and a solitary M2 occlusion remains unclear. Through a pooled analysis of 3 interventional stroke trials, the authors sought to analyze the impact of successful early reperfusion of M2
S S Ghosh et al.
Bioconjugate chemistry, 1(1), 71-76 (1990-01-01)
Two general methods which exploit the reactivity of sulfhydryl groups toward maleimides are described for the synthesis of oligonucleotide-enzyme conjugates for use as nonradioisotopic hybridization probes. In the first approach, 6-maleimidohexanoic acid succinimido ester was used to couple 5'-thiolated oligonucleotide
Nathalie E Blachère et al.
European journal of immunology, 44(11), 3240-3251 (2014-08-12)
Paraneoplastic neurologic diseases (PND) involving immune responses directed toward intracellular antigens are poorly understood. Here, we examine immunity to the PND antigen Nova2, which is expressed exclusively in central nervous system (CNS) neurons. We hypothesized that ectopic expression of neuronal
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